Human Gene MIDEAS (ENST00000286523.9_10) from GENCODE V47lift37

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Description: mitotic deacetylase associated SANT domain protein, transcript variant 1 (from RefSeq NM_194278.4)
Gencode Transcript: ENST00000286523.9_10
Gencode Gene: ENSG00000156030.14_14
Transcript (Including UTRs)
Position: hg19 chr14:74,181,834-74,227,001 Size: 45,168 Total Exon Count: 12 Strand: -
Coding Region
Position: hg19 chr14:74,186,004-74,206,711 Size: 20,708 Coding Exon Count: 11

Page Index	Sequence and Links	UniProtKB Comments	Primers	Gene Alleles	RNA-Seq Expression
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr14:74,181,834-74,227,001)			mRNA (may differ from genome)		Protein (1045 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	MGI
PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: EMSA1_HUMAN DESCRIPTION: RecName: Full=ELM2 and SANT domain-containing protein 1; SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Contains 1 ELM2 domain. SIMILARITY: Contains 1 SANT domain. SEQUENCE CAUTION: Sequence=AAH06511.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 18.65 RPKM in Skin - Sun Exposed (Lower leg) Total median expression: 401.68 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-374.30	783	-0.478	Picture	PostScript	Text
3' UTR	-1521.50	4170	-0.365	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000949 - ELM2_dom
IPR009057 - Homeodomain-like
IPR001005 - SANT/Myb
IPR017884 - SANT_dom

Pfam Domains:
PF01448 - ELM2 domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on Q6PJG2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0008134 transcription factor binding GO:0044212 transcription regulatory region DNA binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0000118 histone deacetylase complex GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005667 transcription factor complex

Descriptions from all associated GenBank mRNAs


	BC052976 - Homo sapiens chromosome 14 open reading frame 43, mRNA (cDNA clone IMAGE:6193955), with apparent retained intron. AB385229 - Synthetic construct DNA, clone: pF1KB9471, Homo sapiens C14orf43 gene for C14orf43 protein, complete cds, without stop codon, in Flexi system. BC006511 - Homo sapiens chromosome 14 open reading frame 43, mRNA (cDNA clone IMAGE:3010441), partial cds. BC025330 - Homo sapiens chromosome 14 open reading frame 43, mRNA (cDNA clone IMAGE:4111658), partial cds. BC006451 - Homo sapiens, clone IMAGE:3960432, mRNA. BC003121 - Homo sapiens, clone IMAGE:3357079, mRNA. BC015668 - Homo sapiens chromosome 14 open reading frame 43, mRNA (cDNA clone IMAGE:4328688), partial cds. BC009202 - Homo sapiens chromosome 14 open reading frame 43, mRNA (cDNA clone IMAGE:3614143), partial cds. AK127785 - Homo sapiens cDNA FLJ45886 fis, clone OCBBF3021361. BC105996 - Homo sapiens cDNA clone IMAGE:4776214. AK024978 - Homo sapiens cDNA: FLJ21325 fis, clone COL02408, highly similar to AF147723 Homo sapiens lipopolysaccharide specific response-68 protein (LSR68) mRNA. BC036475 - Homo sapiens cDNA clone IMAGE:5259265. BC047633 - Homo sapiens chromosome 14 open reading frame 43, mRNA (cDNA clone IMAGE:4818554). BC034345 - Homo sapiens cDNA clone IMAGE:4750481. BC062730 - Homo sapiens cDNA clone IMAGE:6672804, partial cds. AK095434 - Homo sapiens cDNA FLJ38115 fis, clone D3OST2002452. LF209593 - JP 2014500723-A/17096: Polycomb-Associated Non-Coding RNAs. LF329958 - JP 2014500723-A/137461: Polycomb-Associated Non-Coding RNAs. JD311795 - Sequence 292819 from Patent EP1572962. JD476726 - Sequence 457750 from Patent EP1572962. JD069739 - Sequence 50763 from Patent EP1572962. JD379671 - Sequence 360695 from Patent EP1572962. JD560691 - Sequence 541715 from Patent EP1572962. JD119789 - Sequence 100813 from Patent EP1572962. JD371277 - Sequence 352301 from Patent EP1572962. JD414484 - Sequence 395508 from Patent EP1572962. JD514440 - Sequence 495464 from Patent EP1572962. JD542915 - Sequence 523939 from Patent EP1572962. JD560952 - Sequence 541976 from Patent EP1572962. JD165228 - Sequence 146252 from Patent EP1572962. LF329959 - JP 2014500723-A/137462: Polycomb-Associated Non-Coding RNAs. DL492052 - Novel nucleic acids. DL490601 - Novel nucleic acids. AK308604 - Homo sapiens cDNA, FLJ98645. JD479949 - Sequence 460973 from Patent EP1572962. MA565535 - JP 2018138019-A/137461: Polycomb-Associated Non-Coding RNAs. MA565536 - JP 2018138019-A/137462: Polycomb-Associated Non-Coding RNAs. MA445170 - JP 2018138019-A/17096: Polycomb-Associated Non-Coding RNAs. AK021512 - Homo sapiens cDNA FLJ11450 fis, clone HEMBA1001432. AK090424 - Homo sapiens mRNA for FLJ00335 protein. JD519887 - Sequence 500911 from Patent EP1572962. JD064165 - Sequence 45189 from Patent EP1572962. JD393152 - Sequence 374176 from Patent EP1572962. JD522814 - Sequence 503838 from Patent EP1572962. JD126367 - Sequence 107391 from Patent EP1572962. JD052249 - Sequence 33273 from Patent EP1572962. L37690 - Homo sapiens (clone 95) macronuclear mRNA. L37692 - Homo sapiens (clone 88) macronuclear mRNA. JD485531 - Sequence 466555 from Patent EP1572962. JD395265 - Sequence 376289 from Patent EP1572962. JD159798 - Sequence 140822 from Patent EP1572962. JD400095 - Sequence 381119 from Patent EP1572962. JD390960 - Sequence 371984 from Patent EP1572962. JD260915 - Sequence 241939 from Patent EP1572962. JD419362 - Sequence 400386 from Patent EP1572962. JD261341 - Sequence 242365 from Patent EP1572962. JD348437 - Sequence 329461 from Patent EP1572962. JD436227 - Sequence 417251 from Patent EP1572962. JD418885 - Sequence 399909 from Patent EP1572962. JD132887 - Sequence 113911 from Patent EP1572962. JD070743 - Sequence 51767 from Patent EP1572962. JD103999 - Sequence 85023 from Patent EP1572962. JD436458 - Sequence 417482 from Patent EP1572962. JD464584 - Sequence 445608 from Patent EP1572962. JD458784 - Sequence 439808 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: C14orf117 , C14orf43 , ELMSAN1 , ENST00000286523.1, ENST00000286523.2, ENST00000286523.3, ENST00000286523.4, ENST00000286523.5, ENST00000286523.6, ENST00000286523.7, ENST00000286523.8, MDEAS_HUMAN, MIDEAS , NM_194278, Q6PJG2, Q6PK13, Q6PK59, Q6ZS23, uc317kki.1, uc317kki.2 UCSC ID: ENST00000286523.9_10 RefSeq Accession: NM_194278.4 Protein: Q6PJG2 (aka EMSA1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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