ID:EIF3C_HUMAN DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 3 subunit C; Short=eIF3c; AltName: Full=Eukaryotic translation initiation factor 3 subunit 8; AltName: Full=eIF3 p110; FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. SUBUNIT: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Interacts with IFIT1 and IFIT2. INTERACTION: O00571:DDX3X; NbExp=3; IntAct=EBI-353741, EBI-353779; Q9Q2G4:ORF (xeno); NbExp=5; IntAct=EBI-353741, EBI-6248094; SUBCELLULAR LOCATION: Cytoplasm (By similarity). PTM: Phosphorylated. Phosphorylation is enhanced upon serum stimulation. MASS SPECTROMETRY: Mass=106143.8; Method=Unknown; Range=1-913; Source=PubMed:17322308; MASS SPECTROMETRY: Mass=106855; Mass_error=40; Method=MALDI; Range=1-913; Source=PubMed:18599441; SIMILARITY: Belongs to the eIF-3 subunit C family. SIMILARITY: Contains 1 PCI domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/EIF3CID44187ch16p11.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99613
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK292155 - Homo sapiens cDNA FLJ78287 complete cds, highly similar to Homo sapiens eukaryotic translation initiation factor 3, subunit 8,110kDa (EIF3S8), mRNA. BC157842 - Homo sapiens eukaryotic translation initiation factor 3, subunit C-like, mRNA (cDNA clone MGC:189737 IMAGE:9057061), complete cds. BC107692 - Homo sapiens eukaryotic translation initiation factor 3, subunit C, mRNA (cDNA clone IMAGE:4296645), partial cds. AK301183 - Homo sapiens cDNA FLJ55450 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 8. AK301233 - Homo sapiens cDNA FLJ53378 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 8. AK304500 - Homo sapiens cDNA FLJ54404 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 8. AK055366 - Homo sapiens cDNA FLJ30804 fis, clone FEBRA2001267, highly similar to Eukaryotic translation initiation factor 3 subunit 8. AK299421 - Homo sapiens cDNA FLJ55750 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 8. AK303790 - Homo sapiens cDNA FLJ54400 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 8. BC001571 - Homo sapiens eukaryotic translation initiation factor 3, subunit C, mRNA (cDNA clone MGC:5500 IMAGE:3452953), complete cds. BC000533 - Homo sapiens eukaryotic translation initiation factor 3, subunit C, mRNA (cDNA clone IMAGE:2964655), complete cds. AY762099 - Homo sapiens cell migration-inducing protein 17 mRNA, complete cds. AK293264 - Homo sapiens cDNA FLJ54488 complete cds, highly similar to Eukaryotic translation initiation factor 3 subunit 8. AK000739 - Homo sapiens cDNA FLJ20732 fis, clone HEP08682. BC071705 - Homo sapiens eukaryotic translation initiation factor 3, subunit C, mRNA (cDNA clone MGC:87986 IMAGE:5552014), complete cds. BC157849 - Homo sapiens eukaryotic translation initiation factor 3, subunit C, mRNA (cDNA clone MGC:189744 IMAGE:9057068), complete cds. AB527254 - Synthetic construct DNA, clone: pF1KB5403, Homo sapiens EIF3S8 gene for eukaryotic translation initiation factor 3, subunit C, without stop codon, in Flexi system. KJ892588 - Synthetic construct Homo sapiens clone ccsbBroadEn_01982 EIF3C gene, encodes complete protein. DQ891632 - Synthetic construct clone IMAGE:100004262; FLH178813.01X; RZPDo839H05128D eukaryotic translation initiation factor 3, subunit 8, 110kDa (EIF3S8) gene, encodes complete protein. DQ894822 - Synthetic construct Homo sapiens clone IMAGE:100009282; FLH178809.01L; RZPDo839H05127D eukaryotic translation initiation factor 3, subunit 8, 110kDa (EIF3S8) gene, encodes complete protein. DQ572068 - Homo sapiens piRNA piR-40180, complete sequence. AK130531 - Homo sapiens cDNA FLJ27021 fis, clone SLV06146, highly similar to Eukaryotic translation initiation factor 3 subunit 8. BX648075 - Homo sapiens mRNA; cDNA DKFZp686M21210 (from clone DKFZp686M21210). JD022087 - Sequence 3111 from Patent EP1572962. JD034920 - Sequence 15944 from Patent EP1572962. BC021066 - Homo sapiens cDNA clone IMAGE:3509356, **** WARNING: chimeric clone ****. DQ575985 - Homo sapiens piRNA piR-44097, complete sequence. DQ583273 - Homo sapiens piRNA piR-50385, complete sequence. BT007335 - Homo sapiens eukaryotic translation initiation factor 3, subunit 8, 110kDa mRNA, complete cds. DQ590323 - Homo sapiens piRNA piR-57435, complete sequence. JD430643 - Sequence 411667 from Patent EP1572962. JD303750 - Sequence 284774 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q99613 (Reactome details) participates in the following event(s):
R-HSA-72676 eIF3 and eIF1A bind to the 40S subunit R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-72691 Formation of the 43S pre-initiation complex R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72621 Ribosomal scanning R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72649 Translation initiation complex formation R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-156827 L13a-mediated translation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
