Human Gene EID1 (ENST00000530028.3_5) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: EID1_HUMAN
DESCRIPTION: RecName: Full=EP300-interacting inhibitor of differentiation 1; AltName: Full=21 kDa pRb-associated protein; AltName: Full=CREBBP/EP300 inhibitory protein 1; AltName: Full=E1A-like inhibitor of differentiation 1; Short=EID-1;
FUNCTION: Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.
SUBUNIT: Interacts via its LXCXE motif with the entire pocket region of RB1. Interacts with EP300, NR0B2 and TRIM27.
INTERACTION: P25233:Ndn (xeno); NbExp=5; IntAct=EBI-1049975, EBI-1801080;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=May shuttle between nucleus and cytoplasm.
TISSUE SPECIFICITY: Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and various leukemia cell lines.
DEVELOPMENTAL STAGE: Expression decreased with development in ventricular tissue while remaining highly expressed in adult atrial tissue. In primary cultures of human skeletal myocytes, expression decreased during myogenic differentiation (at protein level).
INDUCTION: Down-regulated in differentiating U937 leukemia cells.
PTM: Ubiquitinated in U-2OS osteosarcoma cells and is rapidly degraded by proteasome as cells exit the cell cycle exit.
MISCELLANEOUS: Inhibition of MYOD1 may be partly due to the ability of EID1 to bind and inhibit EP300 histone acetyltransferase activity.
SEQUENCE CAUTION: Sequence=AAK07524.1; Type=Erroneous initiation;
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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ModBase Predicted Comparative 3D Structure on Q9Y6B2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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BC114946 - Homo sapiens EP300 interacting inhibitor of differentiation 1, mRNA (cDNA clone MGC:138884 IMAGE:40084266), complete cds.
BC114944 - Homo sapiens EP300 interacting inhibitor of differentiation 1, mRNA (cDNA clone MGC:138883 IMAGE:40084263), complete cds.
AK315365 - Homo sapiens cDNA, FLJ96411, Homo sapiens CREBBP/EP300 inhibitory protein 1 (CRI1), mRNA.
AF109873 - Homo sapiens retinoblastoma protein-associated protein mRNA, complete cds.
AF092135 - Homo sapiens PTD014 mRNA, complete cds.
AF349444 - Homo sapiens Rb- and p300-binding protein EID-1 mRNA, complete cds.
AK098383 - Homo sapiens cDNA FLJ25517 fis, clone CBR06646.
AL109701 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 45620.
BC024151 - Homo sapiens EP300 interacting inhibitor of differentiation 1, mRNA (cDNA clone IMAGE:4025843), with apparent retained intron.
AL357456 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 222180.
BC007944 - Homo sapiens EP300 interacting inhibitor of differentiation 1, mRNA (cDNA clone IMAGE:4298065), with apparent retained intron.
AB527924 - Synthetic construct DNA, clone: pF1KB0955, Homo sapiens EID1 gene for EP300 interacting inhibitor of differentiation 1, without stop codon, in Flexi system.
KJ893442 - Synthetic construct Homo sapiens clone ccsbBroadEn_02836 EID1 gene, encodes complete protein.
AF274951 - Homo sapiens PNAS-26 mRNA, complete cds.
AF274947 - Homo sapiens PNAS-22 mRNA, complete cds.
JD229062 - Sequence 210086 from Patent EP1572962.
JD049919 - Sequence 30943 from Patent EP1572962.
JD082820 - Sequence 63844 from Patent EP1572962.
JD469868 - Sequence 450892 from Patent EP1572962.
AL137570 - Homo sapiens mRNA; cDNA DKFZp586L0921 (from clone DKFZp586L0921).
JD511770 - Sequence 492794 from Patent EP1572962.
JD280978 - Sequence 262002 from Patent EP1572962.
JD085748 - Sequence 66772 from Patent EP1572962.
JD360725 - Sequence 341749 from Patent EP1572962.
JD042282 - Sequence 23306 from Patent EP1572962.
JD356792 - Sequence 337816 from Patent EP1572962.
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Other Names for This Gene
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Alternate Gene Symbols: B2RD11, C15orf3, CRI1 , EID1 , EID1_HUMAN, ENST00000530028.1, ENST00000530028.2, NM_014335, PNAS-22, PTD014, Q8N7I4, Q9BZT9, Q9Y6B2, RBP21, uc324gwi.1, uc324gwi.2
UCSC ID: ENST00000530028.3_5
RefSeq Accession: NM_014335.3
Protein: Q9Y6B2
(aka EID1_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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US Server
