Human Gene EEF1G (ENST00000329251.5_7) from GENCODE V47lift37

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Description: eukaryotic translation elongation factor 1 gamma (from RefSeq NM_001404.5)
Gencode Transcript: ENST00000329251.5_7
Gencode Gene: ENSG00000254772.10_10
Transcript (Including UTRs)
Position: hg19 chr11:62,327,068-62,341,363 Size: 14,296 Total Exon Count: 10 Strand: -
Coding Region
Position: hg19 chr11:62,327,151-62,341,314 Size: 14,164 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:62,327,068-62,341,363)			mRNA (may differ from genome)		Protein (437 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q53YD7_HUMAN DESCRIPTION: SubName: Full=EEF1G protein; SubName: Full=Eukaryotic translation elongation factor 1 gamma; SubName: Full=Eukaryotic translation elongation factor 1 gamma, isoform CRA_c; SubName: Full=GIG35; SIMILARITY: Contains 1 EF-1-gamma C-terminal domain. SIMILARITY: Contains 1 GST C-terminal domain. SIMILARITY: Contains 1 GST N-terminal domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C023514 2,6-dinitrotoluene C019499 2-nitrofluorene C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone D015127 9,10-Dimethyl-1,2-benzanthracene D016604 Aflatoxin B1 D000638 Amiodarone D001553 Benzbromarone D001564 Benzo(a)pyrene D002330 Carmustine more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-6.30	49	-0.129	Picture	PostScript	Text
3' UTR	-18.60	83	-0.224	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR010987 - Glutathione-S-Trfase_C-like
IPR004045 - Glutathione_S-Trfase_N
IPR017933 - Glutathione_S_Trfase/Cl_chnl_C
IPR004046 - GST_C
IPR012336 - Thioredoxin-like_fold
IPR001662 - Transl_elong_EF1_G_con

Pfam Domains:
PF00043 - Glutathione S-transferase, C-terminal domain
PF00647 - Elongation factor 1 gamma, conserved domain
PF02798 - Glutathione S-transferase, N-terminal domain
PF13410 - Glutathione S-transferase, C-terminal domain
PF13417 - Glutathione S-transferase, N-terminal domain
PF14497 - Glutathione S-transferase, C-terminal domain

SCOP Domains:
47616 - GST C-terminal domain-like
52833 - Thioredoxin-like
89942 - eEF1-gamma domain

ModBase Predicted Comparative 3D Structure on Q53YD7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003746 translation elongation factor activity Biological Process: GO:0006412 translation GO:0006414 translational elongation

Descriptions from all associated GenBank mRNAs


	BC021974 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone IMAGE:3658994), partial cds. BC024274 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone IMAGE:4582973). AF119850 - Homo sapiens PRO1608 mRNA, complete cds. BC007949 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone IMAGE:4299475), partial cds. BC019051 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone IMAGE:4636237). BC006509 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone MGC:2540 IMAGE:2961341), complete cds. BC006520 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone MGC:4231 IMAGE:2961341), complete cds. BC000384 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone MGC:8423 IMAGE:2821006), complete cds. BC009865 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone MGC:16391 IMAGE:3938904), complete cds. BC015813 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone MGC:9621 IMAGE:3911362), complete cds. BC018857 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone IMAGE:3141750). BC018853 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone IMAGE:3141197). BC004142 - Homo sapiens cDNA clone IMAGE:2959823, ** WARNING: chimeric clone **. BC028179 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone MGC:40101 IMAGE:5402023), complete cds. BC013918 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone MGC:22883 IMAGE:4048470), complete cds. BC067738 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone MGC:86978 IMAGE:5295336), complete cds. BC031012 - Homo sapiens eukaryotic translation elongation factor 1 gamma, mRNA (cDNA clone MGC:32765 IMAGE:4654721), complete cds. M55409 - Homo sapiens pancreatic tumor-related protein mRNA, partial cds. AK092787 - Homo sapiens cDNA FLJ35468 fis, clone SMINT2005688, highly similar to ELONGATION FACTOR 1-GAMMA. AK299876 - Homo sapiens cDNA FLJ59973 complete cds, highly similar to Elongation factor 1-gamma. AK129569 - Homo sapiens cDNA FLJ26058 fis, clone PRS03791, highly similar to Elongation factor 1-gamma. AK129618 - Homo sapiens cDNA FLJ26107 fis, clone SPL04844, highly similar to Elongation factor 1-gamma. AK300729 - Homo sapiens cDNA FLJ59433 complete cds, highly similar to Elongation factor 1-gamma. X63526 - H.sapiens mRNA for protein homologous to elongation factor 1-gamma from A.salina. AK130026 - Homo sapiens cDNA FLJ26516 fis, clone KDN07753, highly similar to Elongation factor 1-gamma. AK300203 - Homo sapiens cDNA FLJ56389 complete cds, highly similar to Elongation factor 1-gamma. AK074061 - Homo sapiens mRNA for FLJ00132 protein. AY542307 - Homo sapiens GIG35 mRNA, complete cds. Z11531 - H.sapiens mRNA for elongation factor-1-gamma. JD508750 - Sequence 489774 from Patent EP1572962. JD130680 - Sequence 111704 from Patent EP1572962. JD259909 - Sequence 240933 from Patent EP1572962. AK300686 - Homo sapiens cDNA FLJ59991 complete cds, highly similar to Elongation factor 1-gamma. KJ901403 - Synthetic construct Homo sapiens clone ccsbBroadEn_10797 EEF1G gene, encodes complete protein. KJ896747 - Synthetic construct Homo sapiens clone ccsbBroadEn_06141 EEF1G gene, encodes complete protein. BT006677 - Homo sapiens eukaryotic translation elongation factor 1 gamma mRNA, complete cds. KJ905735 - Synthetic construct Homo sapiens clone ccsbBroadEn_15405 EEF1G gene, encodes complete protein. KJ905736 - Synthetic construct Homo sapiens clone ccsbBroadEn_15406 EEF1G gene, encodes complete protein. DQ891103 - Synthetic construct clone IMAGE:100003733; FLH169360.01X; RZPDo839B0596D eukaryotic translation elongation factor 1 gamma (EEF1G) gene, encodes complete protein. DQ894284 - Synthetic construct Homo sapiens clone IMAGE:100008744; FLH169357.01L; RZPDo839B0595D eukaryotic translation elongation factor 1 gamma (EEF1G) gene, encodes complete protein. CR407625 - Homo sapiens full open reading frame cDNA clone RZPDo834C122D for gene EEF1G, eukaryotic translation elongation factor 1 gamma complete cds, without stopcodon. AB527934 - Synthetic construct DNA, clone: pF1KB0972, Homo sapiens EEF1G gene for eukaryotic translation elongation factor 1 gamma, without stop codon, in Flexi system. JD300105 - Sequence 281129 from Patent EP1572962. KF274542 - Homo sapiens minisatellite 33.15 tagged transcript pAKT-30 sequence. CU675873 - Synthetic construct Homo sapiens gateway clone IMAGE:100018881 5' read EEF1G mRNA. JD514527 - Sequence 495551 from Patent EP1572962. HZ409116 - JP 2015528002-A/1713: CHIRAL CONTROL. LG052450 - KR 1020150036642-A/1716: CHIRAL CONTROL. JD357568 - Sequence 338592 from Patent EP1572962. CU677463 - Synthetic construct Homo sapiens gateway clone IMAGE:100017266 5' read EEF1G mRNA. DQ185034 - Homo sapiens eukaryotic translation elongation factor 1 gamma mRNA, partial cds. AY687925 - Homo sapiens eukaryotic translation elongation factor 1 gamma-like (EEF1G) mRNA, partial sequence. CU680700 - Synthetic construct Homo sapiens gateway clone IMAGE:100017265 5' read EEF1G mRNA. CU674184 - Synthetic construct Homo sapiens gateway clone IMAGE:100017267 5' read EEF1G mRNA. JD020648 - Sequence 1672 from Patent EP1572962. DQ185040 - Homo sapiens eukaryotic translation elongation factor 1 gamma mRNA, partial cds. DQ595848 - Homo sapiens piRNA piR-61960, complete sequence. JD024442 - Sequence 5466 from Patent EP1572962. JD023649 - Sequence 4673 from Patent EP1572962. JD033446 - Sequence 14470 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: EEF1G , ENST00000329251.1, ENST00000329251.2, ENST00000329251.3, ENST00000329251.4, hCG_2039458 , NM_001404, Q53YD7, Q53YD7_HUMAN, uc317srq.1, uc317srq.2 UCSC ID: ENST00000329251.5_7 RefSeq Accession: NM_001404.5 Protein: Q53YD7

Gene Model Information


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Methods, Credits, and Use Restrictions


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