Human Gene DYNLL1 (ENST00000242577.11_4) from GENCODE V47lift37
  Description: dynein light chain LC8-type 1, transcript variant 3 (from RefSeq NM_003746.3)
Gencode Transcript: ENST00000242577.11_4
Gencode Gene: ENSG00000088986.11_15
Transcript (Including UTRs)
   Position: hg19 chr12:120,933,916-120,936,296 Size: 2,381 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr12:120,934,225-120,936,013 Size: 1,789 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:120,933,916-120,936,296)mRNA (may differ from genome)Protein (89 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DYNLL1
Diseases sorted by gene-association score: chronic intestinal vascular insufficiency (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 122.10 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 2787.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.80110-0.289 Picture PostScript Text
3' UTR -48.47283-0.171 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019763 - Dynein_light_1/2_CS
IPR001372 - Dynein_light_chain_typ-1/2

Pfam Domains:
PF01221 - Dynein light chain type 1

SCOP Domains:
54648 - DLC

ModBase Predicted Comparative 3D Structure on Q6FGH9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details  Gene DetailsGene Details
Gene SorterGene Sorter  Gene SorterGene Sorter
 RGD  WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003774 motor activity
GO:0019899 enzyme binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0097110 scaffold protein binding

Biological Process:
GO:0007017 microtubule-based process
GO:0007286 spermatid development
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0050790 regulation of catalytic activity

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005856 cytoskeleton
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030141 secretory granule
GO:0030286 dynein complex
GO:1904115 axon cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LP895257 - Sequence 121 from Patent EP3253886.
LF206929 - JP 2014500723-A/14432: Polycomb-Associated Non-Coding RNAs.
AK311790 - Homo sapiens cDNA, FLJ92051, Homo sapiens dynein, cytoplasmic, light polypeptide 1 (DNCL1),mRNA.
AK309022 - Homo sapiens cDNA, FLJ99063.
BC100289 - Homo sapiens dynein, light chain, LC8-type 1, mRNA (cDNA clone MGC:117405 IMAGE:6501658), complete cds.
U32944 - Human cytoplasmic dynein light chain 1 (hdlc1) mRNA, complete cds.
BC104244 - Homo sapiens dynein, light chain, LC8-type 1, mRNA (cDNA clone MGC:126137 IMAGE:40033556), complete cds.
BC104245 - Homo sapiens dynein, light chain, LC8-type 1, mRNA (cDNA clone MGC:126138 IMAGE:40033557), complete cds.
JD099520 - Sequence 80544 from Patent EP1572962.
LF359464 - JP 2014500723-A/166967: Polycomb-Associated Non-Coding RNAs.
GQ129277 - Synthetic construct Homo sapiens clone HAIB:100068670; DKFZo004C0836 dynein, light chain, LC8-type 1 protein (DYNLL1) gene, partial cds.
GQ129278 - Synthetic construct Homo sapiens clone HAIB:100068573; DKFZo008C0835 dynein, light chain, LC8-type 1 protein (DYNLL1) gene, complete cds.
KJ892587 - Synthetic construct Homo sapiens clone ccsbBroadEn_01981 DYNLL1 gene, encodes complete protein.
AB590812 - Synthetic construct DNA, clone: pFN21AE1581, Homo sapiens DYNLL1 gene for dynein, light chain, LC8-type 1, without stop codon, in Flexi system.
CR407672 - Homo sapiens full open reading frame cDNA clone RZPDo834D1116D for gene DNCL1, dynein, cytoplasmic, light polypeptide 1 complete cds, without stopcodon.
CR542128 - Homo sapiens full open reading frame cDNA clone RZPDo834B1023D for gene DNCL1, dynein, cytoplasmic, light polypeptide 1; complete cds, incl. stopcodon.
LF359463 - JP 2014500723-A/166966: Polycomb-Associated Non-Coding RNAs.
JD019518 - Sequence 542 from Patent EP1572962.
JD033261 - Sequence 14285 from Patent EP1572962.
JD314689 - Sequence 295713 from Patent EP1572962.
JD349107 - Sequence 330131 from Patent EP1572962.
LF359456 - JP 2014500723-A/166959: Polycomb-Associated Non-Coding RNAs.
MA442506 - JP 2018138019-A/14432: Polycomb-Associated Non-Coding RNAs.
MA595041 - JP 2018138019-A/166967: Polycomb-Associated Non-Coding RNAs.
MA595040 - JP 2018138019-A/166966: Polycomb-Associated Non-Coding RNAs.
MA595033 - JP 2018138019-A/166959: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_Lis1Pathway - Lissencephaly gene (LIS1) in neuronal migration and development

-  Other Names for This Gene
  Alternate Gene Symbols: DNCL1 , DYNLL1 , ENST00000242577.1, ENST00000242577.10, ENST00000242577.2, ENST00000242577.3, ENST00000242577.4, ENST00000242577.5, ENST00000242577.6, ENST00000242577.7, ENST00000242577.8, ENST00000242577.9, hCG_27767 , NM_003746, Q6FGH9, Q6FGH9_HUMAN, uc317ekk.1, uc317ekk.2
UCSC ID: ENST00000242577.11_4
RefSeq Accession: NM_003746.3
Protein: Q6FGH9

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.