ID:DC1L1_HUMAN DESCRIPTION: RecName: Full=Cytoplasmic dynein 1 light intermediate chain 1; Short=LIC1; AltName: Full=Dynein light chain A; Short=DLC-A; AltName: Full=Dynein light intermediate chain 1, cytosolic; FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. SUBUNIT: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with PCNT (By similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. PTM: Phosphorylated during mitosis but not in interphase. SIMILARITY: Belongs to the dynein light intermediate chain family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6G9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000226 microtubule cytoskeleton organization GO:0006888 ER to Golgi vesicle-mediated transport GO:0007018 microtubule-based movement GO:0007049 cell cycle GO:0016032 viral process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0043312 neutrophil degranulation GO:0051301 cell division GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
AF078849 - Homo sapiens dynein light chain-A mRNA, complete cds. AK074348 - Homo sapiens cDNA FLJ23768 fis, clone HEP19282, highly similar to Homo sapiens dynein light chain-A mRNA. BX649189 - Homo sapiens mRNA; cDNA DKFZp686A1525 (from clone DKFZp686A1525). JD410393 - Sequence 391417 from Patent EP1572962. JD084289 - Sequence 65313 from Patent EP1572962. AK293253 - Homo sapiens cDNA FLJ58500 complete cds, highly similar to Cytoplasmic dynein 1 light intermediate chain 1. BC131620 - Homo sapiens dynein, cytoplasmic 1, light intermediate chain 1, mRNA (cDNA clone MGC:149683 IMAGE:40117391), complete cds. JD347105 - Sequence 328129 from Patent EP1572962. JD137432 - Sequence 118456 from Patent EP1572962. JD052705 - Sequence 33729 from Patent EP1572962. AK222573 - Homo sapiens mRNA for dynein light chain-A variant, clone: CAS01968. AK001081 - Homo sapiens cDNA FLJ10219 fis, clone HEMBA1007018, highly similar to Cytoplasmic dynein 1 light intermediate chain 1. AK222653 - Homo sapiens mRNA for dynein light chain-A variant, clone: CBL05746. JD437361 - Sequence 418385 from Patent EP1572962. KJ893833 - Synthetic construct Homo sapiens clone ccsbBroadEn_03227 DYNC1LI1 gene, encodes complete protein. JD020763 - Sequence 1787 from Patent EP1572962. JD033321 - Sequence 14345 from Patent EP1572962. JD056240 - Sequence 37264 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y6G9 (Reactome details) participates in the following event(s):
R-HSA-6798743 Exocytosis of secretory granule membrane proteins R-HSA-6800426 Exocytosis of ficolin-rich granule membrane proteins R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-8849350 RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-6798695 Neutrophil degranulation R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-2132295 MHC class II antigen presentation R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-1280218 Adaptive Immune System R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
