Human Gene DUSP8 (ENST00000397374.8_7) from GENCODE V47lift37

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Description: dual specificity phosphatase 8 (from RefSeq NM_004420.3)
Gencode Transcript: ENST00000397374.8_7
Gencode Gene: ENSG00000184545.11_9
Transcript (Including UTRs)
Position: hg19 chr11:1,575,281-1,593,501 Size: 18,221 Total Exon Count: 7 Strand: -
Coding Region
Position: hg19 chr11:1,577,748-1,587,056 Size: 9,309 Coding Exon Count: 6

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:1,575,281-1,593,501)			mRNA (may differ from genome)		Protein (625 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DUS8_HUMAN DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 8; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Dual specificity protein phosphatase hVH-5; FUNCTION: This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate (By similarity). CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). TISSUE SPECIFICITY: Abundant in brain, heart and skeletal muscle. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. SIMILARITY: Contains 1 rhodanese domain. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004958 Estradiol C006253 pirinixic acid C026137 3-hydroxyacetanilide D015116 5,7-Dihydroxytryptamine D000079 Acetaldehyde D000082 Acetaminophen D000661 Amphetamine D017638 Asbestos, Crocidolite D001564 Benzo(a)pyrene D002110 Caffeine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 35.81 RPKM in Brain - Cerebellum Total median expression: 461.49 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-267.50	479	-0.558	Picture	PostScript	Text
3' UTR	-1020.90	2467	-0.414	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR008343 - MKP
IPR001763 - Rhodanese-like_dom
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS

Pfam Domains:
PF00581 - Rhodanese-like domain
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II
52821 - Rhodanese/Cell cycle control phosphatase

ModBase Predicted Comparative 3D Structure on Q13202


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0008138 protein tyrosine/serine/threonine phosphatase activity GO:0016787 hydrolase activity GO:0016791 phosphatase activity GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity Biological Process: GO:0000188 inactivation of MAPK activity GO:0006470 protein dephosphorylation GO:0016311 dephosphorylation GO:0035335 peptidyl-tyrosine dephosphorylation Cellular Component: GO:0005634 nucleus GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	AK124948 - Homo sapiens cDNA FLJ42958 fis, clone BRSTN2010750. AK124467 - Homo sapiens cDNA FLJ42476 fis, clone BRACE2031389. LF370645 - JP 2014500723-A/178148: Polycomb-Associated Non-Coding RNAs. LF207975 - JP 2014500723-A/15478: Polycomb-Associated Non-Coding RNAs. BC045110 - Homo sapiens dual specificity phosphatase 8, mRNA (cDNA clone MGC:52239 IMAGE:5478677), complete cds. U27193 - Human protein-tyrosine phosphatase mRNA, complete cds. JD367869 - Sequence 348893 from Patent EP1572962. BC038231 - Homo sapiens dual specificity phosphatase 8, mRNA (cDNA clone MGC:46176 IMAGE:5547764), complete cds. JD417229 - Sequence 398253 from Patent EP1572962. JD275548 - Sequence 256572 from Patent EP1572962. JD120139 - Sequence 101163 from Patent EP1572962. JD459259 - Sequence 440283 from Patent EP1572962. MA606222 - JP 2018138019-A/178148: Polycomb-Associated Non-Coding RNAs. MA443552 - JP 2018138019-A/15478: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_dspPathway - Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases Reactome (by CSHL, EBI, and GO) Protein Q13202 (Reactome details) participates in the following event(s): R-HSA-5675376 Cytosolic DUSPs dephosphorylate MAPKs R-HSA-5675373 Nuclear DUSPs dephosphorylate MAPKs R-HSA-112409 RAF-independent MAPK1/3 activation R-HSA-5675221 Negative regulation of MAPK pathway R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: C11orf81, DUS8_HUMAN, ENST00000397374.1, ENST00000397374.2, ENST00000397374.3, ENST00000397374.4, ENST00000397374.5, ENST00000397374.6, ENST00000397374.7, NM_004420, Q13202, Q86SS8, uc318yyt.1, uc318yyt.2, VH5 UCSC ID: ENST00000397374.8_7 RefSeq Accession: NM_004420.3 Protein: Q13202 (aka DUS8_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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