Human Gene DUSP2 (ENST00000288943.5_8) from GENCODE V47lift37
  Description: dual specificity phosphatase 2 (from RefSeq NM_004418.4)
Gencode Transcript: ENST00000288943.5_8
Gencode Gene: ENSG00000158050.6_10
Transcript (Including UTRs)
   Position: hg19 chr2:96,808,908-96,811,179 Size: 2,272 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr2:96,809,562-96,811,093 Size: 1,532 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:96,808,908-96,811,179)mRNA (may differ from genome)Protein (314 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DUS2_HUMAN
DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 2; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Dual specificity protein phosphatase PAC-1;
FUNCTION: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in hematopoietic tissues.
INDUCTION: By mitogens.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 rhodanese domain.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 232.53 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 524.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -24.7086-0.287 Picture PostScript Text
3' UTR -263.70654-0.403 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR008343 - MKP
IPR001763 - Rhodanese-like_dom
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS

Pfam Domains:
PF00102 - Protein-tyrosine phosphatase
PF00581 - Rhodanese-like domain
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II
52821 - Rhodanese/Cell cycle control phosphatase

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1M3G - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q05923
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0008330 protein tyrosine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0051019 mitogen-activated protein kinase binding

Biological Process:
GO:0000188 inactivation of MAPK activity
GO:0001706 endoderm formation
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0031965 nuclear membrane


-  Descriptions from all associated GenBank mRNAs
  L11329 - Homo sapiens protein tyrosine phosphatase (PAC-1) mRNA, complete cds.
AF331843 - Homo sapiens phosphatase mRNA, complete cds.
BC007771 - Homo sapiens dual specificity phosphatase 2, mRNA (cDNA clone MGC:12703 IMAGE:4297852), complete cds.
JD389337 - Sequence 370361 from Patent EP1572962.
LF211844 - JP 2014500723-A/19347: Polycomb-Associated Non-Coding RNAs.
JD214592 - Sequence 195616 from Patent EP1572962.
JD477416 - Sequence 458440 from Patent EP1572962.
JD162118 - Sequence 143142 from Patent EP1572962.
JD310983 - Sequence 292007 from Patent EP1572962.
JD560432 - Sequence 541456 from Patent EP1572962.
JD275003 - Sequence 256027 from Patent EP1572962.
JD154421 - Sequence 135445 from Patent EP1572962.
JD261256 - Sequence 242280 from Patent EP1572962.
JD493979 - Sequence 475003 from Patent EP1572962.
JD466096 - Sequence 447120 from Patent EP1572962.
JD222334 - Sequence 203358 from Patent EP1572962.
JD102667 - Sequence 83691 from Patent EP1572962.
JD204179 - Sequence 185203 from Patent EP1572962.
JD174830 - Sequence 155854 from Patent EP1572962.
JD422778 - Sequence 403802 from Patent EP1572962.
JD230405 - Sequence 211429 from Patent EP1572962.
JD223377 - Sequence 204401 from Patent EP1572962.
JD329353 - Sequence 310377 from Patent EP1572962.
EU832639 - Synthetic construct Homo sapiens clone HAIB:100067668; DKFZo008D1231 dual specificity phosphatase 2 protein (DUSP2) gene, encodes complete protein.
EU832716 - Synthetic construct Homo sapiens clone HAIB:100067745; DKFZo004D1232 dual specificity phosphatase 2 protein (DUSP2) gene, encodes complete protein.
LF212922 - JP 2014500723-A/20425: Polycomb-Associated Non-Coding RNAs.
DQ591837 - Homo sapiens piRNA piR-58949, complete sequence.
JD037947 - Sequence 18971 from Patent EP1572962.
JD203589 - Sequence 184613 from Patent EP1572962.
MA447421 - JP 2018138019-A/19347: Polycomb-Associated Non-Coding RNAs.
MA448499 - JP 2018138019-A/20425: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_dspPathway - Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases

Reactome (by CSHL, EBI, and GO)

Protein Q05923 (Reactome details) participates in the following event(s):

R-HSA-5675373 Nuclear DUSPs dephosphorylate MAPKs
R-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: DUS2_HUMAN, DUSP2 , ENST00000288943.1, ENST00000288943.2, ENST00000288943.3, ENST00000288943.4, NM_004418, PAC1, Q05923, Q53T45, uc317kqx.1, uc317kqx.2
UCSC ID: ENST00000288943.5_8
RefSeq Accession: NM_004418.4
Protein: Q05923 (aka DUS2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.