Human Gene DUSP15 (ENST00000339738.10_6) from GENCODE V47lift37
  Description: dual specificity phosphatase 15, transcript variant 1 (from RefSeq NM_080611.5)
Gencode Transcript: ENST00000339738.10_6
Gencode Gene: ENSG00000149599.16_14
Transcript (Including UTRs)
   Position: hg19 chr20:30,448,880-30,458,330 Size: 9,451 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr20:30,449,206-30,458,140 Size: 8,935 Coding Exon Count: 7 

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RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:30,448,880-30,458,330)mRNA (may differ from genome)Protein (235 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DUS15_HUMAN
DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 15; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=VH1-related member Y; AltName: Full=Vaccinia virus VH1-related dual-specific protein phosphatase Y;
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
INTERACTION: P16333:NCK1; NbExp=2; IntAct=EBI-1752795, EBI-389883; P19174:PLCG1; NbExp=2; IntAct=EBI-1752795, EBI-79387;
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Lipid-anchor; Cytoplasmic side.
TISSUE SPECIFICITY: Highly expressed in testis.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CAUTION: Although assigned as two separate genes (c20orf57 and DUSP15), it is probable that C20orf57 does not exist by itself and is a part of the DUSP15 gene.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 82.62 RPKM in Testis
Total median expression: 168.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -111.40190-0.586 Picture PostScript Text
3' UTR -155.80326-0.478 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020417 - Atypical_DUSP
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR020422 - Dual-sp_phosphatase_subgr_cat
IPR024950 - DUSP
IPR017855 - SMAD_dom-like
IPR008984 - SMAD_FHA_domain
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS

Pfam Domains:
PF00782 - Dual specificity phosphatase, catalytic domain

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1YZ4 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9H1R2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042127 regulation of cell proliferation
GO:0046330 positive regulation of JNK cascade

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  JD024812 - Sequence 5836 from Patent EP1572962.
AK097430 - Homo sapiens cDNA FLJ40111 fis, clone TESTI2008320, moderately similar to Homo sapiens mitogen-activated protein kinase phosphatase x (MKPX) mRNA.
BC056911 - Homo sapiens dual specificity phosphatase 15, mRNA (cDNA clone MGC:65166 IMAGE:6195838), complete cds.
AK091960 - Homo sapiens cDNA FLJ34641 fis, clone KIDNE2016570, highly similar to Homo sapiens dual specificity phosphatase 15 (DUSP15), transcript variant 2, mRNA.
JD558036 - Sequence 539060 from Patent EP1572962.
JD077162 - Sequence 58186 from Patent EP1572962.
JD039036 - Sequence 20060 from Patent EP1572962.
JD228849 - Sequence 209873 from Patent EP1572962.
JD133665 - Sequence 114689 from Patent EP1572962.
JD415798 - Sequence 396822 from Patent EP1572962.
JD497862 - Sequence 478886 from Patent EP1572962.
CU691186 - Synthetic construct Homo sapiens gateway clone IMAGE:100021614 5' read DUSP15 mRNA.
HQ448047 - Synthetic construct Homo sapiens clone IMAGE:100071426; CCSB011976_01 dual specificity phosphatase 15 (DUSP15) gene, encodes complete protein.
KJ900123 - Synthetic construct Homo sapiens clone ccsbBroadEn_09517 DUSP15 gene, encodes complete protein.
JD052311 - Sequence 33335 from Patent EP1572962.
JD236903 - Sequence 217927 from Patent EP1572962.
JD514624 - Sequence 495648 from Patent EP1572962.
JD458326 - Sequence 439350 from Patent EP1572962.
JD128628 - Sequence 109652 from Patent EP1572962.
JD497977 - Sequence 479001 from Patent EP1572962.
JD211552 - Sequence 192576 from Patent EP1572962.
JD542238 - Sequence 523262 from Patent EP1572962.
JD196102 - Sequence 177126 from Patent EP1572962.
JD211405 - Sequence 192429 from Patent EP1572962.
JD148871 - Sequence 129895 from Patent EP1572962.
JD407723 - Sequence 388747 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NH79, A8MVC8, C20orf57 , DUS15_HUMAN, DUSP15 , ENST00000339738.1, ENST00000339738.2, ENST00000339738.3, ENST00000339738.4, ENST00000339738.5, ENST00000339738.6, ENST00000339738.7, ENST00000339738.8, ENST00000339738.9, NM_080611, Q5QP62, Q5QP63, Q5QP65, Q6PGN7, Q8N826, Q9BX24, Q9H1R2, uc317vlg.1, uc317vlg.2, VHY
UCSC ID: ENST00000339738.10_6
RefSeq Accession: NM_080611.5
Protein: Q9H1R2 (aka DUS15_HUMAN or DUSF_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.