ID:DPM1_HUMAN DESCRIPTION: RecName: Full=Dolichol-phosphate mannosyltransferase; EC=2.4.1.83; AltName: Full=Dolichol-phosphate mannose synthase; Short=DPM synthase; AltName: Full=Dolichyl-phosphate beta-D-mannosyltransferase; AltName: Full=Mannose-P-dolichol synthase; Short=MPD synthase; FUNCTION: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins. CATALYTIC ACTIVITY: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate. PATHWAY: Protein modification; protein glycosylation. SUBCELLULAR LOCATION: Endoplasmic reticulum. DISEASE: Defects in DPM1 are the cause of congenital disorder of glycosylation type 1E (CDG1E) [MIM:608799]. CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1E is an autosomal recessive disorder, characterized by severe developmental delay, hypotnia, seizures, and dysmorphic features. SIMILARITY: Belongs to the glycosyltransferase 2 family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DPM1"; WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60762
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006486 protein glycosylation GO:0006506 GPI anchor biosynthetic process GO:0019348 dolichol metabolic process GO:0035268 protein mannosylation GO:0035269 protein O-linked mannosylation
BioCyc Knowledge Library MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS - protein N-glycosylation initial phase (eukaryotic) PWY-7922 - protein O-mannosylation II (mammals, core M1 and core M2) PWY-7979 - protein O-mannosylation III (mammals, core M3)
Reactome (by CSHL, EBI, and GO)
Protein O60762 (Reactome details) participates in the following event(s):
R-HSA-162721 dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose R-HSA-162699 Synthesis of dolichyl-phosphate mannose R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-597592 Post-translational protein modification R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-392499 Metabolism of proteins R-HSA-446203 Asparagine N-linked glycosylation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
