ID:DOHH_HUMAN DESCRIPTION: RecName: Full=Deoxyhypusine hydroxylase; Short=hDOHH; EC=1.14.99.29; AltName: Full=Deoxyhypusine dioxygenase; AltName: Full=Deoxyhypusine monooxygenase; AltName: Full=HEAT-like repeat-containing protein 1; FUNCTION: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor. CATALYTIC ACTIVITY: Protein N(6)-(4-aminobutyl)-L-lysine + AH(2) + O(2) = protein N(6)-((R)-4-amino-2-hydroxybutyl)-L-lysine + A + H(2)O. COFACTOR: Binds 2 Fe(2+) ions per subunit. PATHWAY: Protein modification; eIF5A hypusination. SIMILARITY: Belongs to the deoxyhypusine hydroxylase family. SIMILARITY: Contains 5 HEAT-like PBS-type repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BU89
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q9BU89 (Reactome details) participates in the following event(s):
R-HSA-204662 DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A R-HSA-204626 Hypusine synthesis from eIF5A-lysine R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
