Human Gene DOCK5 (ENST00000276440.12_4) from GENCODE V47lift37

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Description: dedicator of cytokinesis 5, transcript variant 1 (from RefSeq NM_024940.8)
Gencode Transcript: ENST00000276440.12_4
Gencode Gene: ENSG00000147459.18_8
Transcript (Including UTRs)
Position: hg19 chr8:25,042,204-25,273,227 Size: 231,024 Total Exon Count: 52 Strand: +
Coding Region
Position: hg19 chr8:25,042,424-25,268,814 Size: 226,391 Coding Exon Count: 52

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:25,042,204-25,273,227)			mRNA (may differ from genome)		Protein (1870 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DOCK5_HUMAN DESCRIPTION: RecName: Full=Dedicator of cytokinesis protein 5; FUNCTION: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. SUBCELLULAR LOCATION: Cytoplasm (By similarity). DOMAIN: The DHR-2 domain may mediate some GEF activity (By similarity). SIMILARITY: Belongs to the DOCK family. SIMILARITY: Contains 1 DHR-1 domain. SIMILARITY: Contains 1 DHR-2 domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=BAB14962.1; Type=Erroneous initiation; Sequence=BAC86503.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen C006253 pirinixic acid C016403 2,4-dinitrotoluene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000638 Amiodarone D001564 Benzo(a)pyrene D002117 Calcitriol D002737 Chloroprene C523799 MRK 003 D011794 Quercetin D013749 Tetrachlorodibenzodioxin D014212 Tretinoin C006780 bisphenol A C016599 mono-(2-ethylhexyl)phthalate C028007 nickel monoxide C009277 sodium arsenate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 11.94 RPKM in Nerve - Tibial Total median expression: 197.97 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-127.30	220	-0.579	Picture	PostScript	Text
3' UTR	-1218.30	4413	-0.276	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR026791 - DOCK
IPR026799 - DOCK_A
IPR010703 - DOCK_C
IPR001452 - SH3_domain

Pfam Domains:
PF00018 - SH3 domain
PF06920 - Dock homology region 2
PF07653 - Variant SH3 domain
PF14429 - C2 domain in Dock180 and Zizimin proteins
PF14604 - Variant SH3 domain
PF16172 - DOCK N-terminus

SCOP Domains:
48371 - ARM repeat
47655 - STAT
50044 - SH3-domain

ModBase Predicted Comparative 3D Structure on Q9H7D0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005085 guanyl-nucleotide exchange factor activity GO:0005515 protein binding Biological Process: GO:0007264 small GTPase mediated signal transduction GO:0010634 positive regulation of epithelial cell migration GO:1900026 positive regulation of substrate adhesion-dependent cell spreading GO:1904694 negative regulation of vascular smooth muscle contraction GO:1904754 positive regulation of vascular associated smooth muscle cell migration Cellular Component: GO:0005737 cytoplasm GO:0005829 cytosol GO:0005886 plasma membrane GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	AK123607 - Homo sapiens cDNA FLJ41613 fis, clone CTONG3002412, moderately similar to Human DOCK180 protein mRNA. BC137175 - Homo sapiens dedicator of cytokinesis 5, mRNA (cDNA clone MGC:168795 IMAGE:9021172), complete cds. BC137176 - Homo sapiens dedicator of cytokinesis 5, mRNA (cDNA clone MGC:168796 IMAGE:9021173), complete cds. CR749353 - Homo sapiens mRNA; cDNA DKFZp781J211 (from clone DKFZp781J211). AK130123 - Homo sapiens cDNA FLJ26613 fis, clone MPB05565, highly similar to Serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform. BC015352 - Homo sapiens dedicator of cytokinesis 5, mRNA (cDNA clone IMAGE:4429918), with apparent retained intron. BC011877 - Homo sapiens dedicator of cytokinesis 5, mRNA (cDNA clone IMAGE:3347029), complete cds. JD129072 - Sequence 110096 from Patent EP1572962. KJ903262 - Synthetic construct Homo sapiens clone ccsbBroadEn_12656 DOCK5 gene, encodes complete protein. AL832744 - Homo sapiens mRNA; cDNA DKFZp686P1513 (from clone DKFZp686P1513). CR933718 - Homo sapiens mRNA; cDNA DKFZp779M164 (from clone DKFZp779M164). BX648352 - Homo sapiens mRNA; cDNA DKFZp686D14185 (from clone DKFZp686D14185). AK024569 - Homo sapiens cDNA: FLJ20916 fis, clone ADSE00738, highly similar to AF161512 Homo sapiens HSPC163 mRNA. AK126249 - Homo sapiens cDNA FLJ44261 fis, clone TLIVE2001327, moderately similar to Human DOCK180 protein mRNA. BC041761 - Homo sapiens dedicator of cytokinesis 5, mRNA (cDNA clone IMAGE:3912471), partial cds. CR627414 - Homo sapiens mRNA; cDNA DKFZp451J181 (from clone DKFZp451J181). AK024687 - Homo sapiens cDNA: FLJ21034 fis, clone CAE09073. JD535716 - Sequence 516740 from Patent EP1572962. JD530124 - Sequence 511148 from Patent EP1572962. AK022242 - Homo sapiens cDNA FLJ12180 fis, clone MAMMA1000744. AK026663 - Homo sapiens cDNA: FLJ23010 fis, clone LNG00543. JD398097 - Sequence 379121 from Patent EP1572962. JD133995 - Sequence 115019 from Patent EP1572962. JD062058 - Sequence 43082 from Patent EP1572962. JD148524 - Sequence 129548 from Patent EP1572962. JD070747 - Sequence 51771 from Patent EP1572962. JD291633 - Sequence 272657 from Patent EP1572962. JD179589 - Sequence 160613 from Patent EP1572962. JD365284 - Sequence 346308 from Patent EP1572962. JD493855 - Sequence 474879 from Patent EP1572962. JD300835 - Sequence 281859 from Patent EP1572962. JD225292 - Sequence 206316 from Patent EP1572962. JD037731 - Sequence 18755 from Patent EP1572962. JD412149 - Sequence 393173 from Patent EP1572962. JD282710 - Sequence 263734 from Patent EP1572962. JD310872 - Sequence 291896 from Patent EP1572962. JD564134 - Sequence 545158 from Patent EP1572962. JD301121 - Sequence 282145 from Patent EP1572962. JD454311 - Sequence 435335 from Patent EP1572962. JD248583 - Sequence 229607 from Patent EP1572962. JD454814 - Sequence 435838 from Patent EP1572962. AK129574 - Homo sapiens cDNA FLJ26063 fis, clone PRS04788. JD026243 - Sequence 7267 from Patent EP1572962. JD034629 - Sequence 15653 from Patent EP1572962. JD028951 - Sequence 9975 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9H7D0 (Reactome details) participates in the following event(s): R-HSA-1011598 DOCKs bind to RhoGEFs R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-109582 Hemostasis

Other Names for This Gene


	Alternate Gene Symbols: B2RNY0, DOCK5_HUMAN, ENST00000276440.1, ENST00000276440.10, ENST00000276440.11, ENST00000276440.2, ENST00000276440.3, ENST00000276440.4, ENST00000276440.5, ENST00000276440.6, ENST00000276440.7, ENST00000276440.8, ENST00000276440.9, NM_024940, Q5XKD5, Q6AI11, Q6PJS6, Q6ZTS6, Q9H7D0, uc317jkm.1, uc317jkm.2 UCSC ID: ENST00000276440.12_4 RefSeq Accession: NM_024940.8 Protein: Q9H7D0 (aka DOCK5_HUMAN or DOC5_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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