Human Gene DOCK11 (ENST00000276202.9_7) from GENCODE V47lift37
  Description: dedicator of cytokinesis 11 (from RefSeq NM_144658.4)
Gencode Transcript: ENST00000276202.9_7
Gencode Gene: ENSG00000147251.16_14
Transcript (Including UTRs)
   Position: hg19 chrX:117,629,778-117,820,110 Size: 190,333 Total Exon Count: 53 Strand: +
Coding Region
   Position: hg19 chrX:117,629,935-117,819,770 Size: 189,836 Coding Exon Count: 53 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:117,629,778-117,820,110)mRNA (may differ from genome)Protein (2073 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DOC11_HUMAN
DESCRIPTION: RecName: Full=Dedicator of cytokinesis protein 11; AltName: Full=Activated Cdc42-associated guanine nucleotide exchange factor; Short=ACG; AltName: Full=Zizimin-2;
FUNCTION: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity).
SUBUNIT: Interacts with CDC42 (By similarity).
DOMAIN: The DHR-2 domain is necessary for the GEF activity (By similarity).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
MISCELLANEOUS: 'Zizim' means 'spike' in Hebrew.
SIMILARITY: Belongs to the DOCK family.
SIMILARITY: Contains 1 DHR-1 domain.
SIMILARITY: Contains 1 DHR-2 domain.
SIMILARITY: Contains 1 PH domain.
SEQUENCE CAUTION: Sequence=BAB71253.1; Type=Erroneous initiation; Sequence=BAC86230.1; Type=Erroneous initiation; Sequence=CAI41407.1; Type=Erroneous gene model prediction; Sequence=CAI41411.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.18 RPKM in Adipose - Subcutaneous
Total median expression: 241.19 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.30157-0.492 Picture PostScript Text
3' UTR -76.00340-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026791 - DOCK
IPR010703 - DOCK_C
IPR021816 - DOCK_C/D_N
IPR026796 - DOCK_D
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF00169 - PH domain
PF06920 - Dock homology region 2
PF11878 - Domain of unknown function (DUF3398)
PF14429 - C2 domain in Dock180 and Zizimin proteins

SCOP Domains:
48371 - ARM repeat
48508 - Nuclear receptor ligand-binding domain
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on Q5JSL3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017048 Rho GTPase binding

Biological Process:
GO:0001782 B cell homeostasis
GO:0002315 marginal zone B cell differentiation
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0043547 positive regulation of GTPase activity
GO:0051491 positive regulation of filopodium assembly

Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AY692226 - Homo sapiens Cdc42-associated guanine nucleotide exchange factor ACG/DOCK11 mRNA, complete cds.
BC156530 - Synthetic construct Homo sapiens clone IMAGE:100063089, MGC:190687 dedicator of cytokinesis 11 (DOCK11) mRNA, encodes complete protein.
AK124735 - Homo sapiens cDNA FLJ42745 fis, clone BRAWH3000100.
JD024401 - Sequence 5425 from Patent EP1572962.
JD033356 - Sequence 14380 from Patent EP1572962.
JD360227 - Sequence 341251 from Patent EP1572962.
AK125641 - Homo sapiens cDNA FLJ43653 fis, clone SYNOV4002346.
BC042053 - Homo sapiens dedicator of cytokinesis 11, mRNA (cDNA clone IMAGE:5577122), containing frame-shift errors.
AK056684 - Homo sapiens cDNA FLJ32122 fis, clone PEBLM1000144, moderately similar to Trg.
JD302672 - Sequence 283696 from Patent EP1572962.
BC047713 - Homo sapiens dedicator of cytokinesis 11, mRNA (cDNA clone IMAGE:5582516), partial cds.
AK054649 - Homo sapiens cDNA FLJ30087 fis, clone BNGH41000003, highly similar to Homo sapiens dedicator of cytokinesis 11 (DOCK11), mRNA.
BC035593 - Homo sapiens dedicator of cytokinesis 11, mRNA (cDNA clone IMAGE:5583671), partial cds.
JD380594 - Sequence 361618 from Patent EP1572962.
JD535226 - Sequence 516250 from Patent EP1572962.
JD524824 - Sequence 505848 from Patent EP1572962.
JD560191 - Sequence 541215 from Patent EP1572962.
JD304364 - Sequence 285388 from Patent EP1572962.
JD434202 - Sequence 415226 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5JSL3 (Reactome details) participates in the following event(s):

R-HSA-1011598 DOCKs bind to RhoGEFs
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: A6NMF0, DOC11_HUMAN, DOCK11 , ENST00000276202.1, ENST00000276202.2, ENST00000276202.3, ENST00000276202.4, ENST00000276202.5, ENST00000276202.6, ENST00000276202.7, ENST00000276202.8, NM_144658, Q5JSL3, Q66M66, Q6ZUJ5, Q86VU8, Q96MN3, uc317jjv.1, uc317jjv.2, ZIZ2
UCSC ID: ENST00000276202.9_7
RefSeq Accession: NM_144658.4
Protein: Q5JSL3 (aka DOC11_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.