Human Gene DNAJC21 (ENST00000648817.1_5) from GENCODE V47lift37

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Description: DnaJ heat shock protein family (Hsp40) member C21, transcript variant 2 (from RefSeq NM_001012339.3)
Gencode Transcript: ENST00000648817.1_5
Gencode Gene: ENSG00000168724.18_15
Transcript (Including UTRs)
Position: hg19 chr5:34,929,664-34,959,069 Size: 29,406 Total Exon Count: 12 Strand: +
Coding Region
Position: hg19 chr5:34,929,925-34,954,819 Size: 24,895 Coding Exon Count: 12

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	GeneReviews	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:34,929,664-34,959,069)			mRNA (may differ from genome)		Protein (531 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DJC21_HUMAN DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 21; AltName: Full=DnaJ homolog subfamily A member 5; AltName: Full=Protein GS3; FUNCTION: May act as a co-chaperone for HSP70. INTERACTION: Q99551:MTERF; NbExp=2; IntAct=EBI-2654581, EBI-2690033; TISSUE SPECIFICITY: Brain, placenta, kidney and pancreas. SIMILARITY: Contains 2 C2H2-type zinc fingers. SIMILARITY: Contains 1 J domain. SEQUENCE CAUTION: Sequence=AAH65745.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAI07578.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAC87112.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: DNAJC21 Diseases sorted by gene-association score: bone marrow failure syndrome 3* (1341), inherited bone marrow failure syndromes* (400), shwachman-diamond syndrome* (260) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C016403 2,4-dinitrotoluene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D016604 Aflatoxin B1 D000643 Ammonium Chloride D002994 Clofibrate D019833 Genistein D010634 Phenobarbital D013749 Tetrachlorodibenzodioxin more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-140.50	261	-0.538	Picture	PostScript	Text
3' UTR	-1056.10	4250	-0.248	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001623 - DnaJ_N
IPR018253 - Heat_shock_DnaJ_CS
IPR003095 - Hsp_DnaJ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd
IPR022755 - Znf_C2H2_jaz
IPR003604 - Znf_U1

Pfam Domains:
PF00226 - DnaJ domain
PF12171 - Zinc-finger double-stranded RNA-binding
PF12874 - Zinc-finger of C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
46565 - Chaperone J-domain
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q5F1R6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0005515 protein binding GO:0008270 zinc ion binding GO:0046872 metal ion binding Biological Process: GO:0006457 protein folding Cellular Component: GO:0005634 nucleus GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005840 ribosome

Descriptions from all associated GenBank mRNAs


	BC065745 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 21, mRNA (cDNA clone IMAGE:6498385), partial cds. AY177688 - Homo sapiens GS3 protein mRNA, complete cds. AY258422 - Homo sapiens DnaJ domain protein mRNA, complete cds. JD318715 - Sequence 299739 from Patent EP1572962. JD516440 - Sequence 497464 from Patent EP1572962. JD189481 - Sequence 170505 from Patent EP1572962. JD056228 - Sequence 37252 from Patent EP1572962. JD056230 - Sequence 37254 from Patent EP1572962. JD056229 - Sequence 37253 from Patent EP1572962. BC141523 - Synthetic construct Homo sapiens clone IMAGE:100014581, MGC:175316 DnaJ (Hsp40) homolog, subfamily C, member 21 (DNAJC21) mRNA, encodes complete protein. AK127749 - Homo sapiens cDNA FLJ45849 fis, clone OCBBF2014745. BC107577 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 21, mRNA (cDNA clone IMAGE:4307151), partial cds. BC050472 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 21, mRNA (cDNA clone IMAGE:6471558), partial cds. AK054651 - Homo sapiens cDNA FLJ30089 fis, clone BNGH41000013. AK022694 - Homo sapiens cDNA FLJ12632 fis, clone NT2RM4001842. BX648765 - Homo sapiens mRNA; cDNA DKFZp686I05130 (from clone DKFZp686I05130). JD502911 - Sequence 483935 from Patent EP1572962. JD286367 - Sequence 267391 from Patent EP1572962. JD111172 - Sequence 92196 from Patent EP1572962. JD511618 - Sequence 492642 from Patent EP1572962. JD211796 - Sequence 192820 from Patent EP1572962. JD138239 - Sequence 119263 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: DJC21_HUMAN, DNAJA5, NM_001012339, Q3B7J9, Q5F1R6, Q6P086, Q6ZS43, Q86VC6, uc328piq.1, uc328piq.2 UCSC ID: ENST00000648817.1_5 RefSeq Accession: NM_001012339.3 Protein: Q5F1R6 (aka DJC21_HUMAN)

GeneReviews for This Gene


	GeneReviews article(s) related to gene DNAJC21: sds (Shwachman-Diamond Syndrome)

Gene Model Information


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Methods, Credits, and Use Restrictions


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