Human Gene DNAJC11 (ENST00000377577.10_7) from GENCODE V47lift37

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Description: DnaJ heat shock protein family (Hsp40) member C11 (from RefSeq NM_018198.4)
Gencode Transcript: ENST00000377577.10_7
Gencode Gene: ENSG00000007923.17_13
Transcript (Including UTRs)
Position: hg19 chr1:6,694,230-6,761,876 Size: 67,647 Total Exon Count: 16 Strand: -
Coding Region
Position: hg19 chr1:6,695,735-6,761,860 Size: 66,126 Coding Exon Count: 16

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:6,694,230-6,761,876)			mRNA (may differ from genome)		Protein (559 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DJC11_HUMAN DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 11; SIMILARITY: Belongs to the DNAJC11 family. SIMILARITY: Contains 1 J domain. SEQUENCE CAUTION: Sequence=AAH08772.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C035207 4-amino-2,6-dinitrotoluene D001564 Benzo(a)pyrene D002794 Choline D019327 Copper Sulfate D003993 Dibutyl Phthalate D005492 Folic Acid D008715 Methionine D013749 Tetrachlorodibenzodioxin C006780 bisphenol A C018021 cobaltous chloride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 12.97 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 406.45 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	0.00	16	0.000	Picture	PostScript	Text
3' UTR	-586.10	1505	-0.389	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR024586 - DnaJ-like_C11_C
IPR001623 - DnaJ_N
IPR018253 - Heat_shock_DnaJ_CS
IPR003095 - Hsp_DnaJ

Pfam Domains:
PF00226 - DnaJ domain
PF11875 - Domain of unknown function (DUF3395)

SCOP Domains:
46565 - Chaperone J-domain

ModBase Predicted Comparative 3D Structure on Q9NVH1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0042407 cristae formation Cellular Component: GO:0005739 mitochondrion GO:0005741 mitochondrial outer membrane GO:0016020 membrane GO:0001401 mitochondrial sorting and assembly machinery complex GO:0061617 MICOS complex

Descriptions from all associated GenBank mRNAs


	AK025491 - Homo sapiens cDNA: FLJ21838 fis, clone HEP01752, highly similar to AF052158 Homo sapiens clone 24616 mRNA sequence. AL109978 - Novel human gene mapping to chomosome 1. AF306695 - Homo sapiens clone R5' mRNA sequence. AF052158 - Homo sapiens clone 24616 mRNA sequence. AK093709 - Homo sapiens cDNA FLJ36390 fis, clone THYMU2008990. AX748271 - Sequence 1796 from Patent EP1308459. AL833841 - Homo sapiens mRNA; cDNA DKFZp727C181 (from clone DKFZp727C181). BC008772 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 11, mRNA (cDNA clone IMAGE:3139659), partial cds. BC006086 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 11, mRNA (cDNA clone MGC:12593 IMAGE:3946414), complete cds. AK095386 - Homo sapiens cDNA FLJ38067 fis, clone CTONG2015345, highly similar to DnaJ homolog subfamily C member 11. AK001599 - Homo sapiens cDNA FLJ10737 fis, clone NT2RP3001426, weakly similar to DNAJ PROTEIN. JD235496 - Sequence 216520 from Patent EP1572962. JD122575 - Sequence 103599 from Patent EP1572962. JD142279 - Sequence 123303 from Patent EP1572962. JD295851 - Sequence 276875 from Patent EP1572962. JD306833 - Sequence 287857 from Patent EP1572962. JD458952 - Sequence 439976 from Patent EP1572962. JD199114 - Sequence 180138 from Patent EP1572962. JD084853 - Sequence 65877 from Patent EP1572962. JD312308 - Sequence 293332 from Patent EP1572962. JD240478 - Sequence 221502 from Patent EP1572962. JD195024 - Sequence 176048 from Patent EP1572962. JD322131 - Sequence 303155 from Patent EP1572962. JD132215 - Sequence 113239 from Patent EP1572962. JD146058 - Sequence 127082 from Patent EP1572962. JD394687 - Sequence 375711 from Patent EP1572962. JD371503 - Sequence 352527 from Patent EP1572962. JD497010 - Sequence 478034 from Patent EP1572962. JD370697 - Sequence 351721 from Patent EP1572962. JD096020 - Sequence 77044 from Patent EP1572962. JD317878 - Sequence 298902 from Patent EP1572962. JD534383 - Sequence 515407 from Patent EP1572962. JD155657 - Sequence 136681 from Patent EP1572962. JD381615 - Sequence 362639 from Patent EP1572962. JD132236 - Sequence 113260 from Patent EP1572962. JD232508 - Sequence 213532 from Patent EP1572962. JD117453 - Sequence 98477 from Patent EP1572962. BC014145 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 11, mRNA (cDNA clone MGC:20641 IMAGE:4762069), complete cds. AY336749 - Homo sapiens DNAJ domain-containing protein mRNA, complete cds. JD439026 - Sequence 420050 from Patent EP1572962. JD419674 - Sequence 400698 from Patent EP1572962. JD030749 - Sequence 11773 from Patent EP1572962. JD020437 - Sequence 1461 from Patent EP1572962. JD126012 - Sequence 107036 from Patent EP1572962. JD068633 - Sequence 49657 from Patent EP1572962. JD470836 - Sequence 451860 from Patent EP1572962. JD373085 - Sequence 354109 from Patent EP1572962. JD126681 - Sequence 107705 from Patent EP1572962. JD364191 - Sequence 345215 from Patent EP1572962. JD223617 - Sequence 204641 from Patent EP1572962. JD446829 - Sequence 427853 from Patent EP1572962. JD406045 - Sequence 387069 from Patent EP1572962. AK298378 - Homo sapiens cDNA FLJ59729 complete cds, highly similar to DnaJ homolog subfamily C member 11. JD400628 - Sequence 381652 from Patent EP1572962. JD382362 - Sequence 363386 from Patent EP1572962. JD160047 - Sequence 141071 from Patent EP1572962. AK294539 - Homo sapiens cDNA FLJ53979 complete cds, highly similar to DnaJ homolog subfamily C member 11. JD186105 - Sequence 167129 from Patent EP1572962. JD317139 - Sequence 298163 from Patent EP1572962. HQ447595 - Synthetic construct Homo sapiens clone IMAGE:100070938; CCSB014704_02 DnaJ (Hsp40) homolog, subfamily C, member 11 (DNAJC11) gene, encodes complete protein. KJ899180 - Synthetic construct Homo sapiens clone ccsbBroadEn_08574 DNAJC11 gene, encodes complete protein. KJ902869 - Synthetic construct Homo sapiens clone ccsbBroadEn_12263 DNAJC11 gene, encodes complete protein. AF306694 - Homo sapiens clone 305-9E mRNA sequence. CU675235 - Synthetic construct Homo sapiens gateway clone IMAGE:100023074 5' read DNAJC11 mRNA. CU680804 - Synthetic construct Homo sapiens gateway clone IMAGE:100019720 5' read DNAJC11 mRNA. AF306696 - Homo sapiens clone R6r/1-6H mRNA sequence.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9NVH1 (Reactome details) participates in the following event(s): R-HSA-8949613 Cristae formation R-HSA-1592230 Mitochondrial biogenesis R-HSA-1852241 Organelle biogenesis and maintenance

Other Names for This Gene


	Alternate Gene Symbols: DJC11_HUMAN, ENST00000377577.1, ENST00000377577.2, ENST00000377577.3, ENST00000377577.4, ENST00000377577.5, ENST00000377577.6, ENST00000377577.7, ENST00000377577.8, ENST00000377577.9, NM_018198, Q4VWF5, Q5VZN0, Q6PK20, Q6PK70, Q8NDM2, Q96CL7, Q9NVH1, uc318nsg.1, uc318nsg.2 UCSC ID: ENST00000377577.10_7 RefSeq Accession: NM_018198.4 Protein: Q9NVH1 (aka DJC11_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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