ID:DNAI2_HUMAN DESCRIPTION: RecName: Full=Dynein intermediate chain 2, axonemal; AltName: Full=Axonemal dynein intermediate chain 2; FUNCTION: Part of the dynein complex of respiratory cilia. SUBUNIT: Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with DNAAF2 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme (By similarity). TISSUE SPECIFICITY: Highly expressed in trachea and testis. DISEASE: Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9) [MIM:612444]. CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. SIMILARITY: Belongs to the dynein intermediate chain family. SIMILARITY: Contains 5 WD repeats. SEQUENCE CAUTION: Sequence=CAB70790.1; Type=Miscellaneous discrepancy; Note=Intron retention;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9GZS0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
