ID:DLG4_HUMAN DESCRIPTION: RecName: Full=Disks large homolog 4; AltName: Full=Postsynaptic density protein 95; Short=PSD-95; AltName: Full=Synapse-associated protein 90; Short=SAP-90; Short=SAP90; FUNCTION: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). SUBUNIT: Interacts with ANKS1B, KLHL17 and PRR7 (By similarity). Interacts through its PDZ domains with NETO1. Interacts through its first two PDZ domains with GRIN2A, GRIN2B, GRIN2C, GRIN2D, ASIC3, certain splice forms of GRIN1, KCND2, CXADR and SYNGAP1. Interacts through its second PDZ domain with the PDZ domain of NOS1 or the C-terminus of CAPON. May interact with HTR2A. Interacts through its guanylate kinase-like domain with DLGAP1/GKAP, DLGAP2, DLGAP3, DLGAP4, MAP1A and BEGAIN. Interacts through its third PDZ domain with CRIPT (By similarity). Interacts through its first two PDZ domains with KCNA1, KCNA2, KCNA3, KCNA4 and ERBB4. Interacts through its first PDZ domain with GRIK2, KCNA4 and CRIPT. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with KIF13B. Isoform 2 interacts through an L27 domain with HGS/HRS and the first L27 domain of CASK. Interacts with LRFN1, LRFN2 and LRFN4. Interacts with ANO2, ADAM22 and LGI1 (By similarity). Interacts with FRMPD4 (via C- terminus). Interacts (via PDZ1 and PDZ2 domains) with LRRC4; LRRC4B and SEMA4C. Interacts (via guanylate kinase-like domain) with SIPA1L1 (By similarity). INTERACTION: P97836-5:Dlgap1 (xeno); NbExp=3; IntAct=EBI-80389, EBI-6269434; Q15303:ERBB4; NbExp=6; IntAct=EBI-80389, EBI-80371; P10499:Kcna1 (xeno); NbExp=2; IntAct=EBI-80389, EBI-631463; P63142:Kcna2 (xeno); NbExp=2; IntAct=EBI-80389, EBI-631446; P15384:Kcna3 (xeno); NbExp=2; IntAct=EBI-80389, EBI-631478; P15385:Kcna4 (xeno); NbExp=9; IntAct=EBI-80389, EBI-631417; O60333-3:KIF1B; NbExp=4; IntAct=EBI-80389, EBI-465669; SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell junction, synapse, synaptosome (By similarity). Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. TISSUE SPECIFICITY: Brain. DOMAIN: The PDZ domain 3 mediates interaction with ADR1B. DOMAIN: The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to postsynaptic density. PTM: Palmitoylation of isoform 1 is required for targeting to postsynaptic density (By similarity). SIMILARITY: Belongs to the MAGUK family. SIMILARITY: Contains 1 guanylate kinase-like domain. SIMILARITY: Contains 3 PDZ (DHR) domains. SIMILARITY: Contains 1 SH3 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P78352
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0002091 negative regulation of receptor internalization GO:0007165 signal transduction GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007268 chemical synaptic transmission GO:0007399 nervous system development GO:0007612 learning GO:0016188 synaptic vesicle maturation GO:0034220 ion transmembrane transport GO:0035176 social behavior GO:0035418 protein localization to synapse GO:0035641 locomotory exploration behavior GO:0035865 cellular response to potassium ion GO:0045184 establishment of protein localization GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity GO:0046037 GMP metabolic process GO:0046710 GDP metabolic process GO:0048169 regulation of long-term neuronal synaptic plasticity GO:0050806 positive regulation of synaptic transmission GO:0050885 neuromuscular process controlling balance GO:0060997 dendritic spine morphogenesis GO:0061098 positive regulation of protein tyrosine kinase activity GO:0065003 macromolecular complex assembly GO:0071625 vocalization behavior GO:0097113 AMPA glutamate receptor clustering GO:0097120 receptor localization to synapse GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000463 positive regulation of excitatory postsynaptic potential GO:2000821 regulation of grooming behavior
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
