ID:DLG2_HUMAN DESCRIPTION: RecName: Full=Disks large homolog 2; AltName: Full=Channel-associated protein of synapse-110; Short=Chapsyn-110; AltName: Full=Postsynaptic density protein PSD-93; FUNCTION: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). SUBUNIT: Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. INTERACTION: P35561:Kcnj2 (xeno); NbExp=6; IntAct=EBI-663057, EBI-703793; SUBCELLULAR LOCATION: Membrane; Lipid-anchor (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Concentrated in soma and postsynaptic density of a subset of neurons (By similarity). DOMAIN: An N-terminally truncated L27 domain is predicted in isoform 2 at positions 1 through 27. PTM: Palmitoylation of isoform 1 is not required for targeting to postsynaptic density (By similarity). SIMILARITY: Belongs to the MAGUK family. SIMILARITY: Contains 1 guanylate kinase-like domain. SIMILARITY: Contains 3 PDZ (DHR) domains. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=BAD92489.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15700
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007268 chemical synaptic transmission GO:0007399 nervous system development GO:0010923 negative regulation of phosphatase activity GO:0019233 sensory perception of pain GO:0035865 cellular response to potassium ion GO:0043113 receptor clustering GO:0046037 GMP metabolic process GO:0046710 GDP metabolic process GO:0097120 receptor localization to synapse GO:0099641 anterograde axonal protein transport GO:0099642 retrograde axonal protein transport GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
