Human Gene DIRAS3 (ENST00000646789.1_6) from GENCODE V47lift37

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Description: DIRAS family GTPase 3 (from RefSeq NM_004675.5)
Gencode Transcript: ENST00000646789.1_6
Gencode Gene: ENSG00000162595.8_12
Transcript (Including UTRs)
Position: hg19 chr1:68,511,645-68,516,310 Size: 4,666 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr1:68,512,291-68,512,980 Size: 690 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:68,511,645-68,516,310)			mRNA (may differ from genome)		Protein (229 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DIRA3_HUMAN DESCRIPTION: RecName: Full=GTP-binding protein Di-Ras3; AltName: Full=Distinct subgroup of the Ras family member 3; AltName: Full=Rho-related GTP-binding protein RhoI; Flags: Precursor; INTERACTION: P40763:STAT3; NbExp=3; IntAct=EBI-6139214, EBI-518675; SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). TISSUE SPECIFICITY: Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers. SIMILARITY: Belongs to the small GTPase superfamily. Di-Ras family. WEB RESOURCE: Name=Wikipedia; Note=NOEY2 entry; URL="http://en.wikipedia.org/wiki/NOEY2";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D016572 Cyclosporine D004958 Estradiol D004397 Fonofos D015474 Isotretinoin D018021 Lithium Chloride D010278 Parathion C012568 terbufos

Common Gene Haplotype Alleles


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-49.40	145	-0.341	Picture	PostScript	Text
3' UTR	-129.70	646	-0.201	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR020849 - Small_GTPase_Ras

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

ModBase Predicted Comparative 3D Structure on O95661


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003924 GTPase activity GO:0005515 protein binding GO:0005525 GTP binding Biological Process: GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0006349 regulation of gene expression by genetic imprinting GO:0007165 signal transduction GO:0007264 small GTPase mediated signal transduction Cellular Component: GO:0005622 intracellular GO:0005886 plasma membrane GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	U96750 - Homo sapiens putative tumor supressor NOEY2 mRNA, complete cds. BC005362 - Homo sapiens DIRAS family, GTP-binding RAS-like 3, mRNA (cDNA clone MGC:12468 IMAGE:3686616), complete cds. AK096393 - Homo sapiens cDNA FLJ39074 fis, clone NT2RP7016622, highly similar to Homo sapiens small GTP-binding tumor suppressor (ARHI) gene. JD220763 - Sequence 201787 from Patent EP1572962. AK021882 - Homo sapiens cDNA FLJ11820 fis, clone HEMBA1006445, highly similar to GTP-binding protein Di-Ras3. JD237964 - Sequence 218988 from Patent EP1572962. JD491065 - Sequence 472089 from Patent EP1572962. JD346919 - Sequence 327943 from Patent EP1572962. JD442638 - Sequence 423662 from Patent EP1572962. JD475867 - Sequence 456891 from Patent EP1572962. CR541870 - Homo sapiens full open reading frame cDNA clone RZPDo834F1132D for gene ARHI, ras homolog gene family, member I; complete cds, incl. stopcodon. KJ892681 - Synthetic construct Homo sapiens clone ccsbBroadEn_02075 DIRAS3 gene, encodes complete protein. DQ893059 - Synthetic construct clone IMAGE:100005689; FLH193158.01X; RZPDo839D0478D DIRAS family, GTP-binding RAS-like 3 (DIRAS3) gene, encodes complete protein. DQ896309 - Synthetic construct Homo sapiens clone IMAGE:100010769; FLH193154.01L; RZPDo839D0468D DIRAS family, GTP-binding RAS-like 3 (DIRAS3) gene, encodes complete protein. AB464509 - Synthetic construct DNA, clone: pF1KB8768, Homo sapiens DIRAS3 gene for DIRAS family, GTP-binding RAS-like 3, without stop codon, in Flexi system. CR541892 - Homo sapiens full open reading frame cDNA clone RZPDo834A0833D for gene ARHI, ras homolog gene family, member I; complete cds, without stopcodon. JD120763 - Sequence 101787 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ARHI, B3KMP3, DIRA3_HUMAN, NM_004675, NOEY2, O95661, RHOI, uc328mwf.1, uc328mwf.2 UCSC ID: ENST00000646789.1_6 RefSeq Accession: NM_004675.5 Protein: O95661 (aka DIRA3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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