ID:DHX8_HUMAN DESCRIPTION: RecName: Full=ATP-dependent RNA helicase DHX8; EC=3.6.4.13; AltName: Full=DEAH box protein 8; AltName: Full=RNA helicase HRH1; FUNCTION: Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Identified in the spliceosome C complex. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. SUBCELLULAR LOCATION: Nucleus. DOMAIN: The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome. SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. SIMILARITY: Contains 1 S1 motif domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14562
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
