ID:DEN6B_HUMAN DESCRIPTION: RecName: Full=Protein DENND6B; AltName: Full=DENN domain-containing protein 6B; FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35. SUBCELLULAR LOCATION: Recycling endosome (Potential). Cytoplasm (Potential). SIMILARITY: Belongs to the DENND6 family. CAUTION: Identified as having similarity to the core DENN family and referred to as DENN6B (PubMed:21330364). Prediction methods do not indicate a DENN domain for this sequence and, the exact role of the DENN or this DENN-like domain in GEF activity needs to be clarified.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02141 - DENN (AEX-3) domain PF08616 - Stabilization of polarity axis PF09794 - Transport protein Avl9
ModBase Predicted Comparative 3D Structure on Q8NEG7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
