Human Gene DDT (ENST00000398344.9_7) from GENCODE V47lift37

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Description: D-dopachrome tautomerase, transcript variant 4 (from RefSeq NM_001397485.1)
Gencode Transcript: ENST00000398344.9_7
Gencode Gene: ENSG00000099977.16_11
Transcript (Including UTRs)
Position: hg19 chr22:24,313,559-24,316,630 Size: 3,072 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr22:24,313,740-24,316,603 Size: 2,864 Coding Exon Count: 3

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr22:24,313,559-24,316,630)			mRNA (may differ from genome)		Protein (118 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	ExonPrimer	GeneCards	HGNC
Human Cortex Gene Expression	Malacards	MGI	PubMed	UniProtKB	Wikipedia

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: DDT Diseases sorted by gene-association score: disuse amblyopia (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D001564 Benzo(a)pyrene C049325 1,2-dithiol-3-thione C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane D000082 Acetaminophen D000643 Ammonium Chloride D019256 Cadmium Chloride D002251 Carbon Tetrachloride D002994 Clofibrate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 67.93 RPKM in Liver Total median expression: 757.27 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-1.90	27	-0.070	Picture	PostScript	Text
3' UTR	-48.40	181	-0.267	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001398 - Macrophage_inhib_fac
IPR019829 - Macrophage_inhib_fac_CS
IPR014347 - Tautomerase

Pfam Domains:
PF01187 - Macrophage migration inhibitory factor (MIF)

SCOP Domains:
56014 - Nitrite and sulphite reductase 4Fe-4S domain-like
55331 - Tautomerase/MIF

ModBase Predicted Comparative 3D Structure on Q53Y51


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details			Gene Details
Gene Sorter	Gene Sorter			Gene Sorter
	RGD	Ensembl		WormBase

Descriptions from all associated GenBank mRNAs


	AK304122 - Homo sapiens cDNA FLJ59607 complete cds, moderately similar to D-dopachrome decarboxylase (EC 4.1.1.84). AK315943 - Homo sapiens cDNA, FLJ78842 complete cds, moderately similar to D-dopachrome decarboxylase (EC 4.1.1.84). U84143 - Human D-dopachrome tautomerase mRNA, complete cds. BC015508 - Homo sapiens D-dopachrome tautomerase, mRNA (cDNA clone MGC:9158 IMAGE:3902943), complete cds. U49785 - Human D-dopachrome tautomerase mRNA, complete cds. BC005971 - Homo sapiens D-dopachrome tautomerase, mRNA (cDNA clone MGC:14637 IMAGE:4082777), complete cds. AK292044 - Homo sapiens cDNA FLJ76419 complete cds, highly similar to Homo sapiens D-dopachrome tautomerase (DDT), mRNA. JD261983 - Sequence 243007 from Patent EP1572962. JD259923 - Sequence 240947 from Patent EP1572962. CR456431 - Homo sapiens DDT full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.DDT). CU012991 - Homo sapiens DDT, mRNA (cDNA clone IMAGE:100000153), complete cds, with stop codon, in Gateway system. BT006970 - Homo sapiens D-dopachrome tautomerase mRNA, complete cds. DQ891571 - Synthetic construct clone IMAGE:100004201; FLH178244.01X; RZPDo839A12128D D-dopachrome tautomerase (DDT) gene, encodes complete protein. DQ894765 - Synthetic construct Homo sapiens clone IMAGE:100009225; FLH178240.01L; RZPDo839A12127D D-dopachrome tautomerase (DDT) gene, encodes complete protein. CU013279 - Homo sapiens DDT, mRNA (cDNA clone IMAGE:100000057), complete cds, without stop codon, in Gateway system. AK298326 - Homo sapiens cDNA FLJ51263 complete cds, moderately similar to D-dopachrome decarboxylase (EC 4.1.1.84). AK296189 - Homo sapiens cDNA FLJ60602 complete cds, moderately similar to D-dopachrome decarboxylase (EC 4.1.1.84). JD128654 - Sequence 109678 from Patent EP1572962. JD235589 - Sequence 216613 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: DDT , DDT1 , ENST00000398344.1, ENST00000398344.2, ENST00000398344.3, ENST00000398344.4, ENST00000398344.5, ENST00000398344.6, ENST00000398344.7, ENST00000398344.8, hCG_41098 , NM_001397485, Q53Y51, Q53Y51_HUMAN, uc318zqx.1, uc318zqx.2 UCSC ID: ENST00000398344.9_7 RefSeq Accession: NM_001084392.3 Protein: Q53Y51

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.