Human Gene DDOST (ENST00000602624.7_13) from GENCODE V47lift37

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Description: dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit (from RefSeq NM_005216.5)
Gencode Transcript: ENST00000602624.7_13
Gencode Gene: ENSG00000244038.11_15
Transcript (Including UTRs)
Position: hg19 chr1:20,978,270-20,987,862 Size: 9,593 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr1:20,978,872-20,987,843 Size: 8,972 Coding Exon Count: 11

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Pathways
Other Names	GeneReviews	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:20,978,270-20,987,862)			mRNA (may differ from genome)		Protein (439 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: DDOST Diseases sorted by gene-association score: congenital disorder of glycosylation, type ir* (1600) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016572 Cyclosporine C006780 bisphenol A D016604 Aflatoxin B1 D002994 Clofibrate D002995 Clofibric Acid D019327 Copper Sulfate D004147 Dioxins D004958 Estradiol D004997 Ethinyl Estradiol D005839 Gentamicins more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 125.87 RPKM in Cells - Cultured fibroblasts Total median expression: 2689.32 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-3.10	19	-0.163	Picture	PostScript	Text
3' UTR	-201.10	602	-0.334	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser
Gene Details	Gene Details		Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter		Gene Sorter
	RGD	Ensembl			SGD
					Protein Sequence
					Alignment

Descriptions from all associated GenBank mRNAs


	AK090466 - Homo sapiens mRNA for FLJ00387 protein. LP886331 - Sequence 223 from Patent WO2017201352. LP978088 - Sequence 223 from Patent WO2017120612. BC002594 - Homo sapiens dolichyl-diphosphooligosaccharide-protein glycosyltransferase, mRNA (cDNA clone MGC:2191 IMAGE:3161588), complete cds. JD482642 - Sequence 463666 from Patent EP1572962. JD366418 - Sequence 347442 from Patent EP1572962. JD534800 - Sequence 515824 from Patent EP1572962. JD292561 - Sequence 273585 from Patent EP1572962. JD092090 - Sequence 73114 from Patent EP1572962. JD517547 - Sequence 498571 from Patent EP1572962. JD440195 - Sequence 421219 from Patent EP1572962. JD421440 - Sequence 402464 from Patent EP1572962. JD257004 - Sequence 238028 from Patent EP1572962. JD325410 - Sequence 306434 from Patent EP1572962. AK297009 - Homo sapiens cDNA FLJ55714 complete cds, highly similar to Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor (EC 2.4.1.119). JD511654 - Sequence 492678 from Patent EP1572962. JD522481 - Sequence 503505 from Patent EP1572962. JD074956 - Sequence 55980 from Patent EP1572962. AK296041 - Homo sapiens cDNA FLJ52929 complete cds, highly similar to Dolichyl-diphosphooligosaccharide--proteinglycosyltransferase 48 kDa subunit precursor (EC2.4.1.119). JD179162 - Sequence 160186 from Patent EP1572962. JD131172 - Sequence 112196 from Patent EP1572962. AB062391 - Homo sapiens OK/SW-cl.45 mRNA for dolichyl-diphosphooligosaccharide-protein glycosyltransferase, complete cds. D29643 - Homo sapiens KIAA0115 mRNA, complete cds. JD077684 - Sequence 58708 from Patent EP1572962. JD207954 - Sequence 188978 from Patent EP1572962. AK315633 - Homo sapiens cDNA, FLJ96720, Homo sapiens dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST), mRNA. KJ896696 - Synthetic construct Homo sapiens clone ccsbBroadEn_06090 DDOST gene, encodes complete protein. AB383753 - Synthetic construct DNA, clone: pF1KSDA0115, Homo sapiens DDOST gene for dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor, complete cds, without stop codon, in Flexi system. DQ891927 - Synthetic construct clone IMAGE:100004557; FLH181496.01X; RZPDo839E01136D dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST) gene, encodes complete protein. DQ895114 - Synthetic construct Homo sapiens clone IMAGE:100009574; FLH181492.01L; RZPDo839E01135D dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST) gene, encodes complete protein. CU678058 - Synthetic construct Homo sapiens gateway clone IMAGE:100018308 5' read DDOST mRNA. JD023095 - Sequence 4119 from Patent EP1572962. JD028803 - Sequence 9827 from Patent EP1572962. MB419110 - JP 2019519516-A/72: MRNA COMBINATION THERAPIES FOR THE TREATMENT OF CANCER. MB419975 - JP 2019519516-A/937: MRNA COMBINATION THERAPIES FOR THE TREATMENT OF CANCER.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS - protein N-glycosylation initial phase (eukaryotic)

Other Names for This Gene


	Alternate Gene Symbols: A0A0C4DGS1, A0A0C4DGS1_HUMAN, DDOST , ENST00000602624.1, ENST00000602624.2, ENST00000602624.3, ENST00000602624.4, ENST00000602624.5, ENST00000602624.6, NM_005216, uc327gun.1, uc327gun.2 UCSC ID: ENST00000602624.7_13 RefSeq Accession: NM_005216.5

GeneReviews for This Gene


	GeneReviews article(s) related to gene DDOST: cdg (Congenital Disorders of N-Linked Glycosylation and Multiple Pathway Overview)

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.