Human Gene DCX (ENST00000636035.2_10) from GENCODE V47lift37

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Description: doublecortin, transcript variant 5 (from RefSeq NM_001195553.2)
Gencode Transcript: ENST00000636035.2_10
Gencode Gene: ENSG00000077279.21_19
Transcript (Including UTRs)
Position: hg19 chrX:110,537,007-110,655,420 Size: 118,414 Total Exon Count: 7 Strand: -
Coding Region
Position: hg19 chrX:110,544,915-110,653,626 Size: 108,712 Coding Exon Count: 6

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	GeneReviews	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chrX:110,537,007-110,655,420)			mRNA (may differ from genome)		Protein (366 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: DCX Diseases sorted by gene-association score: lissencephaly, x-linked* (1603), subcortical band heterotopia* (286), dcx-related disorders* (100), lissencephaly (57), band heterotopia (38), pachygyria (19), neuronal migration disorders (13), retinitis pigmentosa 1 (12), isolated 17-linked lissencephaly (12), heterotopia, periventricular (11), tuberous sclerosis (10), lennox-gastaut syndrome (9), lissencephaly with cerebellar hypoplasia (8), deafness, autosomal recessive 66 (8), epilepsy (8), occult macular dystrophy (6), optic nerve hypoplasia (5), congenital nervous system abnormality (5), agnathia-otocephaly complex (4), autistic disorder (2), physical disorder (1), retinitis pigmentosa (1) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D000643 Ammonium Chloride C038328 BEP protocol D002084 Butylated Hydroxytoluene D002235 Carbofuran D002998 Clonazepam D000431 Ethanol D005472 Fluorouracil D010126 Ozone D010634 Phenobarbital more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-19.60	77	-0.255	Picture	PostScript	Text
3' UTR	-2199.10	7908	-0.278	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR017302 - Doublecortin_chordata
IPR003533 - Doublecortin_dom

Pfam Domains:
PF03607 - Doublecortin

SCOP Domains:
89837 - Doublecortin (DC)

ModBase Predicted Comparative 3D Structure on A8K340


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0001764 neuron migration GO:0007420 brain development GO:0021766 hippocampus development GO:0021819 layer formation in cerebral cortex GO:0021860 pyramidal neuron development GO:0021952 central nervous system projection neuron axonogenesis GO:0035556 intracellular signal transduction GO:0048675 axon extension GO:0048813 dendrite morphogenesis Cellular Component: GO:0005737 cytoplasm GO:0005829 cytosol GO:0043005 neuron projection

Descriptions from all associated GenBank mRNAs


	AJ003112 - Homo sapiens mRNA for doublecortin. AK299822 - Homo sapiens cDNA FLJ51296 complete cds, highly similar to Neuronal migration protein doublecortin. BC027925 - Homo sapiens doublecortin, mRNA (cDNA clone MGC:34242 IMAGE:5240179), complete cds. AF040254 - Homo sapiens doublecortin isoform (DCX) mRNA, complete cds. AF040255 - Homo sapiens doublecortin (DCX) mRNA, complete cds. AK290455 - Homo sapiens cDNA FLJ77057 complete cds, highly similar to Homo sapiens doublecortex; lissencephaly, X-linked (doublecortin) (DCX), transcript variant 2, mRNA. AK297297 - Homo sapiens cDNA FLJ60690 complete cds, highly similar to Neuronal migration protein doublecortin. HQ447825 - Synthetic construct Homo sapiens clone IMAGE:100071168; CCSB008416_01 doublecortex; lissencephaly, X-linked (doublecortin) (DCX) gene, encodes complete protein. KJ891034 - Synthetic construct Homo sapiens clone ccsbBroadEn_00428 DCX gene, encodes complete protein. KR710687 - Synthetic construct Homo sapiens clone CCSBHm_00015594 DCX (DCX) mRNA, encodes complete protein. KR710688 - Synthetic construct Homo sapiens clone CCSBHm_00015595 DCX (DCX) mRNA, encodes complete protein. KR710689 - Synthetic construct Homo sapiens clone CCSBHm_00015613 DCX (DCX) mRNA, encodes complete protein. KR710690 - Synthetic construct Homo sapiens clone CCSBHm_00015636 DCX (DCX) mRNA, encodes complete protein. AF034634 - Homo sapiens doublecortin mRNA, partial cds. JD543571 - Sequence 524595 from Patent EP1572962. JD429928 - Sequence 410952 from Patent EP1572962. JD230696 - Sequence 211720 from Patent EP1572962. JD157931 - Sequence 138955 from Patent EP1572962. JD385526 - Sequence 366550 from Patent EP1572962. JD353925 - Sequence 334949 from Patent EP1572962. AK002120 - Homo sapiens cDNA FLJ11258 fis, clone PLACE1009027, highly similar to Homo sapiens mRNA for doublecortin. JD330146 - Sequence 311170 from Patent EP1572962. JD203211 - Sequence 184235 from Patent EP1572962. JD348014 - Sequence 329038 from Patent EP1572962. JD418205 - Sequence 399229 from Patent EP1572962. JD246199 - Sequence 227223 from Patent EP1572962. JD433993 - Sequence 415017 from Patent EP1572962. JD067014 - Sequence 48038 from Patent EP1572962. JD292933 - Sequence 273957 from Patent EP1572962. JD528775 - Sequence 509799 from Patent EP1572962. JD509989 - Sequence 491013 from Patent EP1572962. JD279256 - Sequence 260280 from Patent EP1572962. JD270149 - Sequence 251173 from Patent EP1572962. JD544225 - Sequence 525249 from Patent EP1572962. JD500497 - Sequence 481521 from Patent EP1572962. JD380656 - Sequence 361680 from Patent EP1572962. JD285212 - Sequence 266236 from Patent EP1572962. JD414245 - Sequence 395269 from Patent EP1572962. JD095358 - Sequence 76382 from Patent EP1572962. JD133453 - Sequence 114477 from Patent EP1572962. JD327899 - Sequence 308923 from Patent EP1572962. JD510716 - Sequence 491740 from Patent EP1572962. JD090796 - Sequence 71820 from Patent EP1572962. JD512262 - Sequence 493286 from Patent EP1572962. JD350871 - Sequence 331895 from Patent EP1572962. JD215723 - Sequence 196747 from Patent EP1572962. JD503911 - Sequence 484935 from Patent EP1572962. JD286481 - Sequence 267505 from Patent EP1572962. JD510371 - Sequence 491395 from Patent EP1572962. JD106851 - Sequence 87875 from Patent EP1572962. JD560633 - Sequence 541657 from Patent EP1572962. JD112960 - Sequence 93984 from Patent EP1572962. JD225354 - Sequence 206378 from Patent EP1572962. JD533904 - Sequence 514928 from Patent EP1572962. JD479042 - Sequence 460066 from Patent EP1572962. JD543532 - Sequence 524556 from Patent EP1572962. JD561037 - Sequence 542061 from Patent EP1572962. JD262176 - Sequence 243200 from Patent EP1572962. JD087164 - Sequence 68188 from Patent EP1572962. JD438736 - Sequence 419760 from Patent EP1572962. JD382354 - Sequence 363378 from Patent EP1572962. JD519412 - Sequence 500436 from Patent EP1572962. JD385551 - Sequence 366575 from Patent EP1572962. JD382723 - Sequence 363747 from Patent EP1572962. JD326528 - Sequence 307552 from Patent EP1572962. JD464241 - Sequence 445265 from Patent EP1572962. JD083971 - Sequence 64995 from Patent EP1572962. JD348312 - Sequence 329336 from Patent EP1572962. JD153966 - Sequence 134990 from Patent EP1572962. JD431918 - Sequence 412942 from Patent EP1572962. JD270998 - Sequence 252022 from Patent EP1572962. JD503730 - Sequence 484754 from Patent EP1572962. JD491004 - Sequence 472028 from Patent EP1572962. JD345093 - Sequence 326117 from Patent EP1572962. JD355210 - Sequence 336234 from Patent EP1572962. JD300025 - Sequence 281049 from Patent EP1572962. JD524909 - Sequence 505933 from Patent EP1572962. JD177605 - Sequence 158629 from Patent EP1572962. JD554407 - Sequence 535431 from Patent EP1572962. JD554231 - Sequence 535255 from Patent EP1572962. JD255627 - Sequence 236651 from Patent EP1572962. JD491778 - Sequence 472802 from Patent EP1572962. JD362264 - Sequence 343288 from Patent EP1572962. JD504134 - Sequence 485158 from Patent EP1572962. JD379937 - Sequence 360961 from Patent EP1572962. JD060303 - Sequence 41327 from Patent EP1572962. JD428749 - Sequence 409773 from Patent EP1572962. JD558474 - Sequence 539498 from Patent EP1572962. JD269410 - Sequence 250434 from Patent EP1572962. JD444257 - Sequence 425281 from Patent EP1572962. JD280418 - Sequence 261442 from Patent EP1572962. JD097797 - Sequence 78821 from Patent EP1572962. JD480365 - Sequence 461389 from Patent EP1572962. JD145552 - Sequence 126576 from Patent EP1572962. JD313997 - Sequence 295021 from Patent EP1572962. JD494767 - Sequence 475791 from Patent EP1572962. JD053097 - Sequence 34121 from Patent EP1572962. JD367742 - Sequence 348766 from Patent EP1572962. JD546642 - Sequence 527666 from Patent EP1572962. JD508982 - Sequence 490006 from Patent EP1572962. JD082165 - Sequence 63189 from Patent EP1572962. JD363028 - Sequence 344052 from Patent EP1572962. JD285673 - Sequence 266697 from Patent EP1572962. JD565461 - Sequence 546485 from Patent EP1572962. JD499290 - Sequence 480314 from Patent EP1572962. JD396213 - Sequence 377237 from Patent EP1572962. JD300115 - Sequence 281139 from Patent EP1572962. JD242991 - Sequence 224015 from Patent EP1572962. JD085394 - Sequence 66418 from Patent EP1572962. JD251660 - Sequence 232684 from Patent EP1572962. CU693320 - Synthetic construct Homo sapiens gateway clone IMAGE:100019082 5' read DCX mRNA. JD311327 - Sequence 292351 from Patent EP1572962. JD409517 - Sequence 390541 from Patent EP1572962. JD298419 - Sequence 279443 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_Lis1Pathway - Lissencephaly gene (LIS1) in neuronal migration and development

Other Names for This Gene


	Alternate Gene Symbols: A8K340, A8K340_HUMAN, DCX , ENST00000636035.1, NM_001195553, uc328ccw.1, uc328ccw.2 UCSC ID: ENST00000636035.2_10 RefSeq Accession: NM_001195553.2 Protein: A8K340

GeneReviews for This Gene


	GeneReviews article(s) related to gene DCX: dcx (DCX-Related Disorders)

Gene Model Information


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Methods, Credits, and Use Restrictions


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