ID:DCTN4_HUMAN DESCRIPTION: RecName: Full=Dynactin subunit 4; Short=Dyn4; AltName: Full=Dynactin subunit p62; FUNCTION: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. SUBUNIT: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not ATP7A, in a copper- dependent manner. Interacts with ANK2; this interaction is required for localization at costameres (By similarity). INTERACTION: Q01484:ANK2; NbExp=1; IntAct=EBI-2134033, EBI-941975; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. SIMILARITY: Belongs to the dynactin subunit 4 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UJW0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0047485 protein N-terminus binding
Biological Process: GO:0006888 ER to Golgi vesicle-mediated transport GO:0007097 nuclear migration GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
AL162085 - Homo sapiens mRNA; cDNA DKFZp761J032 (from clone DKFZp761J032); partial cds. AK000299 - Homo sapiens cDNA FLJ20292 fis, clone HEP05374. AF156165 - Homo sapiens chromosome 5 putative tumor suppressor mRNA, complete sequence. AK125973 - Homo sapiens cDNA FLJ43985 fis, clone TESTI4018938, highly similar to Dynactin subunit 4. BC026323 - Homo sapiens dynactin 4 (p62), mRNA (cDNA clone MGC:26190 IMAGE:4815273), complete cds. JD486376 - Sequence 467400 from Patent EP1572962. JD562978 - Sequence 544002 from Patent EP1572962. JD252706 - Sequence 233730 from Patent EP1572962. JD101123 - Sequence 82147 from Patent EP1572962. JD483488 - Sequence 464512 from Patent EP1572962. JD047191 - Sequence 28215 from Patent EP1572962. JD116743 - Sequence 97767 from Patent EP1572962. JD091452 - Sequence 72476 from Patent EP1572962. JD550800 - Sequence 531824 from Patent EP1572962. AF195120 - Homo sapiens dynactin p62 subunit mRNA, complete cds. JD093192 - Sequence 74216 from Patent EP1572962. AK025873 - Homo sapiens cDNA: FLJ22220 fis, clone HRC01643, highly similar to AF195120 Homo sapiens dynactin p62 subunit mRNA. JD296999 - Sequence 278023 from Patent EP1572962. JD500887 - Sequence 481911 from Patent EP1572962. JD546857 - Sequence 527881 from Patent EP1572962. JD235099 - Sequence 216123 from Patent EP1572962. JD519961 - Sequence 500985 from Patent EP1572962. JD130348 - Sequence 111372 from Patent EP1572962. JD494349 - Sequence 475373 from Patent EP1572962. JD207521 - Sequence 188545 from Patent EP1572962. JD493030 - Sequence 474054 from Patent EP1572962. JD358780 - Sequence 339804 from Patent EP1572962. AK296787 - Homo sapiens cDNA FLJ52515 complete cds, highly similar to Dynactin subunit 4. JD300762 - Sequence 281786 from Patent EP1572962. JD491829 - Sequence 472853 from Patent EP1572962. AK311693 - Homo sapiens cDNA, FLJ18735. JD469586 - Sequence 450610 from Patent EP1572962. JD482384 - Sequence 463408 from Patent EP1572962. AK307757 - Homo sapiens cDNA, FLJ97705. JD370425 - Sequence 351449 from Patent EP1572962. JD413701 - Sequence 394725 from Patent EP1572962. JD374779 - Sequence 355803 from Patent EP1572962. JD273321 - Sequence 254345 from Patent EP1572962. JD318446 - Sequence 299470 from Patent EP1572962. AK299517 - Homo sapiens cDNA FLJ56235 complete cds, highly similar to Dynactin subunit 4. DQ892339 - Synthetic construct clone IMAGE:100004969; FLH185470.01X; RZPDo839B07148D dynactin 4 (p62) (DCTN4) gene, encodes complete protein. KJ898844 - Synthetic construct Homo sapiens clone ccsbBroadEn_08238 DCTN4 gene, encodes complete protein. DQ895544 - Synthetic construct Homo sapiens clone IMAGE:100010004; FLH185466.01L; RZPDo839B07147D dynactin 4 (p62) (DCTN4) gene, encodes complete protein. KU178637 - Homo sapiens dynactin 4 isoform 1 (DCTN4) mRNA, partial cds. KU178638 - Homo sapiens dynactin 4 isoform 2 (DCTN4) mRNA, partial cds, alternatively spliced. KU178639 - Homo sapiens dynactin 4 isoform 3 (DCTN4) mRNA, complete cds, alternatively spliced. DQ572965 - Homo sapiens piRNA piR-41077, complete sequence. CU693212 - Synthetic construct Homo sapiens gateway clone IMAGE:100019502 5' read DCTN4 mRNA. JD351649 - Sequence 332673 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UJW0 (Reactome details) participates in the following event(s):
R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-8849350 RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex R-HSA-2132295 MHC class II antigen presentation R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-1280218 Adaptive Immune System R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-168256 Immune System R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
