ID:DCP2_HUMAN DESCRIPTION: RecName: Full=m7GpppN-mRNA hydrolase; EC=3.6.1.62; AltName: Full=Nucleoside diphosphate-linked moiety X motif 20; Short=Nudix motif 20; AltName: Full=mRNA-decapping enzyme 2; Short=hDpc; FUNCTION: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety. CATALYTIC ACTIVITY: M(7)G5'ppp5'-mRNA + H(2)O = m(7)GDP + 5'- phospho-mRNA. COFACTOR: Manganese. Required for highest activity. Can also utilize magnesium ions. SUBUNIT: Found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, UPF1, UPF2 and UPF3B. Forms a complex with DCP1A, EDC3, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC4/HEDLS. Interacts with DPC1B, UPF1, UPF2 and UPF3B. Interacts (via N-terminus and C-terminus) with TRIM21 (via N-terminus and C-terminus). Associates with polysomes. Interacts with LIMD1, WTIP and AJUBA. Interacts with DDX17 in an RNA-dependent manner. Interacts with ZC3HAV1. INTERACTION: Q9NPI6:DCP1A; NbExp=6; IntAct=EBI-521577, EBI-374238; Q8IZD4:DCP1B; NbExp=3; IntAct=EBI-521577, EBI-521595; Q6P2E9:EDC4; NbExp=4; IntAct=EBI-521577, EBI-1006038; Q92900:UPF1; NbExp=3; IntAct=EBI-521577, EBI-373471; SUBCELLULAR LOCATION: Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the Nudix hydrolase family. DCP2 subfamily. SIMILARITY: Contains 1 nudix hydrolase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IU60
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
