ID:CXCR3_HUMAN DESCRIPTION: RecName: Full=C-X-C chemokine receptor type 3; Short=CXC-R3; Short=CXCR-3; AltName: Full=CKR-L2; AltName: Full=G protein-coupled receptor 9; AltName: Full=Interferon-inducible protein 10 receptor; Short=IP-10 receptor; AltName: CD_antigen=CD183; FUNCTION: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). FUNCTION: Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. FUNCTION: Isoform 3 mediates the activity of CXCL11. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. PTM: Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. PTM: N-glycosylated. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. SEQUENCE CAUTION: Sequence=CAB02143.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CXCR3ID40224chXq13.html"; WEB RESOURCE: Name=Wikipedia; Note=CXC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CXC_chemokine_receptors";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on P49682
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF469635 - Homo sapiens CXC chemokine receptor transcript variant B (GPR9) mRNA, complete cds, alternatively spliced. X95876 - H.sapiens mRNA for G-protein coupled receptor. BC034403 - Homo sapiens chemokine (C-X-C motif) receptor 3, mRNA (cDNA clone MGC:34593 IMAGE:5176136), complete cds. JD075999 - Sequence 57023 from Patent EP1572962. JD255162 - Sequence 236186 from Patent EP1572962. JD519056 - Sequence 500080 from Patent EP1572962. JD364900 - Sequence 345924 from Patent EP1572962. JD474717 - Sequence 455741 from Patent EP1572962. JD247621 - Sequence 228645 from Patent EP1572962. JD133072 - Sequence 114096 from Patent EP1572962. JD375405 - Sequence 356429 from Patent EP1572962. AY242128 - Homo sapiens chemokine (C-X-C motif) receptor 3 (CXCR3) mRNA, complete cds. AK313679 - Homo sapiens cDNA, FLJ94266, highly similar to Homo sapiens chemokine (C-X-C motif) receptor 3 (CXCR3), mRNA. KJ891279 - Synthetic construct Homo sapiens clone ccsbBroadEn_00673 CXCR3 gene, encodes complete protein. DQ892460 - Synthetic construct clone IMAGE:100005090; FLH186529.01X; RZPDo839F0671D chemokine (C-X-C motif) receptor 3 (CXCR3) gene, encodes complete protein. DQ895673 - Synthetic construct Homo sapiens clone IMAGE:100010133; FLH186525.01L; RZPDo839F0661D chemokine (C-X-C motif) receptor 3 (CXCR3) gene, encodes complete protein. KU178101 - Homo sapiens chemokine receptor 3 isoform 1 (CXCR3) mRNA, partial cds. KU178102 - Homo sapiens chemokine receptor 3 isoform 2 (CXCR3) mRNA, partial cds, alternatively spliced. AB464487 - Synthetic construct DNA, clone: pF1KB8825, Homo sapiens CXCR3 gene for chemokine (C-X-C motif) receptor 3, without stop codon, in Flexi system. CU689880 - Synthetic construct Homo sapiens gateway clone IMAGE:100019104 5' read CXCR3 mRNA. JD387226 - Sequence 368250 from Patent EP1572962. JD053450 - Sequence 34474 from Patent EP1572962. JD360876 - Sequence 341900 from Patent EP1572962. JD380123 - Sequence 361147 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_IL12Pathway - IL12 and Stat4 Dependent Signaling Pathway in Th1 Development h_no2il12Pathway - NO2-dependent IL 12 Pathway in NK cells h_mCalpainPathway - mCalpain and friends in Cell motility h_nktPathway - Selective expression of chemokine receptors during T-cell polarization
Reactome (by CSHL, EBI, and GO)
Protein P49682 (Reactome details) participates in the following event(s):
R-HSA-374248 Receptor CXCR3 binds ligands CXCL9 to 11 R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signalling R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-372790 Signaling by GPCR R-HSA-500792 GPCR ligand binding R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
