ID:CTU1_HUMAN DESCRIPTION: RecName: Full=Cytoplasmic tRNA 2-thiolation protein 1; EC=2.7.7.-; AltName: Full=ATP-binding domain-containing protein 3; AltName: Full=Cancer-associated gene protein; AltName: Full=Cytoplasmic tRNA adenylyltransferase 1; FUNCTION: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine- tRNA biosynthesis. SUBUNIT: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z7A3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
