Human Gene CTSB (ENST00000353047.11_12) from GENCODE V47lift37
Description: cathepsin B, transcript variant 1 (from RefSeq NM_001908.5)
Gencode Transcript: ENST00000353047.11_12
Gencode Gene: ENSG00000164733.23_18
Transcript (Including UTRs)
Position: hg19 chr8:11,700,033-11,725,596 Size: 25,564 Total Exon Count: 10 Strand: -
Coding Region
Position: hg19 chr8:11,702,634-11,710,963 Size: 8,330 Coding Exon Count: 9
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: CATB_HUMAN
DESCRIPTION: RecName: Full=Cathepsin B; EC=3.4.22.1; AltName: Full=APP secretase; Short=APPS; AltName: Full=Cathepsin B1; Contains: RecName: Full=Cathepsin B light chain; Contains: RecName: Full=Cathepsin B heavy chain; Flags: Precursor;
FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.CATALYTIC ACTIVITY: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.SUBUNIT: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2.INTERACTION: P40692:MLH1; NbExp=7; IntAct=EBI-715062, EBI-744248;SUBCELLULAR LOCATION: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.SIMILARITY: Belongs to the peptidase C1 family.WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CTSBID40202ch8p23.html";
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: CTSB
Diseases sorted by gene-association score: keratolytic winter erythema * (31), occlusion of gallbladder (16), acute pancreatitis (12), tropical calcific pancreatitis (9), ileum cancer (9), gingival overgrowth (9), laryngostenosis (9), cerebral aneurysms (8), lysosomal acid phosphatase deficiency (8), non-suppurative otitis media (6), bone giant cell tumor (6), tinea favosa (6), mucolipidosis ii alpha/beta (5), chronic tic disorder (5), retinitis pigmentosa 42 (5), amyloidosis aa (5), cercarial dermatitis (5), alzheimer disease (4), pancreatic steatorrhea (4), avoidant personality disorder (4), colorectal cancer (4), juxtacortical osteosarcoma (4), peripheral osteosarcoma (3), lung cancer (2), ovarian cancer, somatic (1), meningioma, familial (1)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D013749
Tetrachlorodibenzodioxin
D000082
Acetaminophen
D001564
Benzo(a)pyrene
C400541
CA 074 methyl ester
D019256
Cadmium Chloride
D002110
Caffeine
D002945
Cisplatin
D002994
Clofibrate
D004052
Diethylnitrosamine
D004054
Diethylstilbestrol
D004317
Doxorubicin
D004726
Endosulfan
D004958
Estradiol
D004997
Ethinyl Estradiol
D019833
Genistein
D005947
Glucose
D007545
Isoproterenol
C014175
pyrazolo(3,4-d)pyrimidine
D014013
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
D015632
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C422565
13beta-methyl 19-nor-steroid
C532162
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
C085911
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
C023035
3,4,5,3',4'-pentachlorobiphenyl
C105260
4-tert-octylphenol
C547126
AZM551248
D016604
Aflatoxin B1
D000452
Aldrin
D000525
Alprazolam
D000643
Ammonium Chloride
D001241
Aspirin
D017963
Azithromycin
D002117
Calcitriol
D002166
Camptothecin
D002251
Carbon Tetrachloride
D002713
Chlorine
D002738
Chloroquine
D004390
Chlorpyrifos
D002995
Clofibric Acid
D003042
Cocaine
D003300
Copper
D019327
Copper Sulfate
D003375
Coumestrol
D003474
Curcumin
D003513
Cycloheximide
D016572
Cyclosporine
D015853
Cysteine Proteinase Inhibitors
D003993
Dibutyl Phthalate
D004026
Dieldrin
D004041
Dietary Fats
D004137
Dinitrochlorobenzene
D004178
Diquat
D004237
Diuron
D000431
Ethanol
D005419
Flavonoids
D005472
Fluorouracil
D005485
Flutamide
D005839
Gentamicins
D006037
Glyoxal
D006861
Hydrogen Peroxide
D006997
Hypochlorous Acid
D007213
Indomethacin
D007657
Ketone Bodies
D001556
Lindane
D008070
Lipopolysaccharides
D058185
Magnetite Nanoparticles
D008294
Malathion
D008550
Melatonin
D008715
Methionine
D008731
Methoxychlor
D008743
Methyl Parathion
D008769
Methylnitronitrosoguanidine
D015741
Metribolone
D009020
Morphine
D037742
Nanotubes, Carbon
D009538
Nicotine
D019319
Okadaic Acid
D010100
Oxygen
D010126
Ozone
D010269
Paraquat
D010615
Phenacetin
D010634
Phenobarbital
D010672
Phenytoin
D028321
Plant Preparations
D011374
Progesterone
D011441
Propylthiouracil
D011692
Puromycin Aminonucleoside
D011739
Pyrimethamine
D011765
Pyruvaldehyde
D011794
Quercetin
D020849
Raloxifene
D012643
Selenium
D012822
Silicon Dioxide
D012999
Soman
D053260
Soot
D004113
Succimer
D013467
Sulindac
D013629
Tamoxifen
D013755
Tetradecanoylphorbol Acetate
D013806
Theophylline
D013853
Thioacetamide
D014028
Tobacco Smoke Pollution
D014031
Tobramycin
D014118
Toxins, Biological
D014212
Tretinoin
D014241
Trichloroethylene
D014271
Trifluridine
D014527
Uric Acid
D014635
Valproic Acid
D014810
Vitamin E
C435690
anilofos
C004984
apocarotenal
C517629
benzyloxycarbonyl-valyl-alanyl-aspartic acid
D019207
beta Carotene
C026609
beta-solamarine
C400082
bortezomib
C054409
butachlor
C040048
caffeic acid
C004656
chloroacetaldehyde
C019304
ciprofibrate
C029892
cupric chloride
C045651
epigallocatechin gallate
C082360
fipronil
C070081
fulvestrant
C056933
fumonisin B1
C043055
gallium arsenide
C010972
glycolaldehyde
C028904
isoproturon
C032854
leupeptin
C008435
methyldithiocarbamate
C005274
naringin
C029938
nickel sulfate
C041786
palm oil
C030299
phenylhydrazine
C006253
pirinixic acid
C009166
retinol acetate
C078903
seocalcitol
C009277
sodium arsenate
D020122
tert-Butylhydroperoxide
C042172
thallium nitrate
C057693
troglitazone
C088658
zoledronic acid
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR025661 - Pept_asp_AS
IPR000169 - Pept_cys_AS
IPR025660 - Pept_his_AS
IPR013128 - Peptidase_C1A
IPR000668 - Peptidase_C1A_C
IPR015643 - Peptidase_C1A_cathepsin-B
IPR012599 - Propeptide_C1A
Pfam Domains: PF00112 - Papain family cysteine protease
PF08127 - Peptidase family C1 propeptide
SCOP Domains: 54001 - Cysteine proteinases
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on P07858
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC095408 - Homo sapiens cathepsin B, mRNA (cDNA clone MGC:110901 IMAGE:30334082), complete cds.LF384999 - JP 2014500723-A/192502: Polycomb-Associated Non-Coding RNAs.AK098296 - Homo sapiens cDNA FLJ40977 fis, clone UTERU2014167.AK097384 - Homo sapiens cDNA FLJ40065 fis, clone TESOP2000400, highly similar to CATHEPSIN B PRECURSOR (EC 3.4.22.1).AK128472 - Homo sapiens cDNA FLJ46616 fis, clone TLIVE2006733.JD558293 - Sequence 539317 from Patent EP1572962.JD564374 - Sequence 545398 from Patent EP1572962.DQ575022 - Homo sapiens piRNA piR-43134, complete sequence.JD119160 - Sequence 100184 from Patent EP1572962.DQ574107 - Homo sapiens piRNA piR-42219, complete sequence.BX648239 - Homo sapiens mRNA; cDNA DKFZp686H09108 (from clone DKFZp686H09108).BX647952 - Homo sapiens mRNA; cDNA DKFZp686H1851 (from clone DKFZp686H1851).L16510 - Homo sapiens cathepsin B mRNA, complete cds.E10341 - cDNA encoding human pro-cathepsin B.M14221 - Human cathepsin B proteinase mRNA, complete cds.AK092070 - Homo sapiens cDNA FLJ34751 fis, clone NESOP2000231, highly similar to CATHEPSIN B PRECURSOR (EC 3.4.22.1).AK130184 - Homo sapiens cDNA FLJ26674 fis, clone MPG03491, highly similar to Cathepsin B precursor (EC 3.4.22.1).AK075393 - Homo sapiens cDNA PSEC0083 fis, clone NT2RP2005506, highly similar to CATHEPSIN B PRECURSOR (EC 3.4.22.1).BX647765 - Homo sapiens mRNA; cDNA DKFZp686N0152 (from clone DKFZp686N0152).BC010240 - Homo sapiens cathepsin B, mRNA (cDNA clone MGC:17266 IMAGE:4154307), complete cds.JD039387 - Sequence 20411 from Patent EP1572962.L22569 - Homo sapiens cathepsin B mRNA, 3' UTR with a stem-loop structure providing mRNA stability.LF334773 - JP 2014500723-A/142276: Polycomb-Associated Non-Coding RNAs.JD290546 - Sequence 271570 from Patent EP1572962.JD340956 - Sequence 321980 from Patent EP1572962.LF334772 - JP 2014500723-A/142275: Polycomb-Associated Non-Coding RNAs.JD455720 - Sequence 436744 from Patent EP1572962.JD084509 - Sequence 65533 from Patent EP1572962.JD359097 - Sequence 340121 from Patent EP1572962.LF334771 - JP 2014500723-A/142274: Polycomb-Associated Non-Coding RNAs.JD148766 - Sequence 129790 from Patent EP1572962.JD026000 - Sequence 7024 from Patent EP1572962.JD036169 - Sequence 17193 from Patent EP1572962.LF334770 - JP 2014500723-A/142273: Polycomb-Associated Non-Coding RNAs.JD355553 - Sequence 336577 from Patent EP1572962.JD456214 - Sequence 437238 from Patent EP1572962.JD075571 - Sequence 56595 from Patent EP1572962.JD111456 - Sequence 92480 from Patent EP1572962.JD239183 - Sequence 220207 from Patent EP1572962.JD362605 - Sequence 343629 from Patent EP1572962.DL491830 - Novel nucleic acids.LF334768 - JP 2014500723-A/142271: Polycomb-Associated Non-Coding RNAs.DL490404 - Novel nucleic acids.AK296845 - Homo sapiens cDNA FLJ58073 complete cds, moderately similar to Cathepsin B precursor (EC 3.4.22.1).AK297687 - Homo sapiens cDNA FLJ59133 complete cds, highly similar to Cathepsin B precursor (EC 3.4.22.1).AK290239 - Homo sapiens cDNA FLJ78235 complete cds.M13230 - Human lysosomal proteinase cathepsin B mRNA, 3' end.GQ891351 - Homo sapiens clone HEL-S-124f epididymis secretory sperm binding protein mRNA, complete cds.AB385099 - Synthetic construct DNA, clone: pF1KB5441, Homo sapiens CTSB gene for cathepsin B precursor, complete cds, without stop codon, in Flexi system.LF334766 - JP 2014500723-A/142269: Polycomb-Associated Non-Coding RNAs.LF334765 - JP 2014500723-A/142268: Polycomb-Associated Non-Coding RNAs.Y18460 - Homo sapiens mRNA for cathepsin B, partial.LF334764 - JP 2014500723-A/142267: Polycomb-Associated Non-Coding RNAs.DQ591997 - Homo sapiens piRNA piR-59109, complete sequence.LF334763 - JP 2014500723-A/142266: Polycomb-Associated Non-Coding RNAs.LF334762 - JP 2014500723-A/142265: Polycomb-Associated Non-Coding RNAs.LF334761 - JP 2014500723-A/142264: Polycomb-Associated Non-Coding RNAs.DL491519 - Novel nucleic acids.DL490128 - Novel nucleic acids.LF334760 - JP 2014500723-A/142263: Polycomb-Associated Non-Coding RNAs.LF334758 - JP 2014500723-A/142261: Polycomb-Associated Non-Coding RNAs.LF334756 - JP 2014500723-A/142259: Polycomb-Associated Non-Coding RNAs.JD342047 - Sequence 323071 from Patent EP1572962.JD404762 - Sequence 385786 from Patent EP1572962.JD200526 - Sequence 181550 from Patent EP1572962.JD380211 - Sequence 361235 from Patent EP1572962.MA620576 - JP 2018138019-A/192502: Polycomb-Associated Non-Coding RNAs.MA570350 - JP 2018138019-A/142276: Polycomb-Associated Non-Coding RNAs.MA570349 - JP 2018138019-A/142275: Polycomb-Associated Non-Coding RNAs.MA570348 - JP 2018138019-A/142274: Polycomb-Associated Non-Coding RNAs.MA570347 - JP 2018138019-A/142273: Polycomb-Associated Non-Coding RNAs.MA570345 - JP 2018138019-A/142271: Polycomb-Associated Non-Coding RNAs.MA570343 - JP 2018138019-A/142269: Polycomb-Associated Non-Coding RNAs.MA570342 - JP 2018138019-A/142268: Polycomb-Associated Non-Coding RNAs.MA570341 - JP 2018138019-A/142267: Polycomb-Associated Non-Coding RNAs.MA570340 - JP 2018138019-A/142266: Polycomb-Associated Non-Coding RNAs.MA570339 - JP 2018138019-A/142265: Polycomb-Associated Non-Coding RNAs.MA570338 - JP 2018138019-A/142264: Polycomb-Associated Non-Coding RNAs.MA570337 - JP 2018138019-A/142263: Polycomb-Associated Non-Coding RNAs.MA570335 - JP 2018138019-A/142261: Polycomb-Associated Non-Coding RNAs.MA570333 - JP 2018138019-A/142259: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: B3KQR5, B3KRR5, CATB_HUMAN, CPSB, ENST00000353047.1, ENST00000353047.10, ENST00000353047.2, ENST00000353047.3, ENST00000353047.4, ENST00000353047.5, ENST00000353047.6, ENST00000353047.7, ENST00000353047.8, ENST00000353047.9, NM_001908, P07858, Q503A6, Q96D87, uc317yih.1, uc317yih.2UCSC ID: ENST00000353047.11_12RefSeq Accession: NM_001908.5
Protein: P07858
(aka CATB_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.