ID:CTDS1_HUMAN DESCRIPTION: RecName: Full=Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; EC=3.1.3.16; AltName: Full=Nuclear LIM interactor-interacting factor 3; Short=NLI-IF; Short=NLI-interacting factor 3; AltName: Full=Small C-terminal domain phosphatase 1; Short=SCP1; Short=Small CTD phosphatase 1; FUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 1 magnesium ion per monomer. ENZYME REGULATION: Stimulated by GTF2F1. Inhibited by beryllofluoride anions. BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 5; SUBUNIT: Monomer (By similarity). Interacts with GTF2F1. Interacts with REST. SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with RNA polymerase II. TISSUE SPECIFICITY: Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta. SIMILARITY: Contains 1 FCP1 homology domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9GZU7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001933 negative regulation of protein phosphorylation GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006470 protein dephosphorylation GO:0045665 negative regulation of neuron differentiation GO:0050768 negative regulation of neurogenesis GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
