Human Gene CRYZ (ENST00000340866.10_7) from GENCODE V47lift37
  Description: crystallin zeta, transcript variant 2 (from RefSeq NM_001889.4)
Gencode Transcript: ENST00000340866.10_7
Gencode Gene: ENSG00000116791.14_14
Transcript (Including UTRs)
   Position: hg19 chr1:75,171,170-75,198,734 Size: 27,565 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr1:75,171,980-75,190,505 Size: 18,526 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:75,171,170-75,198,734)mRNA (may differ from genome)Protein (329 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: QOR_HUMAN
DESCRIPTION: RecName: Full=Quinone oxidoreductase; EC=1.6.5.5; AltName: Full=NADPH:quinone reductase; AltName: Full=Zeta-crystallin;
FUNCTION: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.
CATALYTIC ACTIVITY: NADPH + 2 quinone = NADP(+) + 2 semiquinone.
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Only very low amounts in the lens.
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 40.31 RPKM in Kidney - Cortex
Total median expression: 467.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.40108-0.235 Picture PostScript Text
3' UTR -157.80810-0.195 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013149 - ADH_C
IPR013154 - ADH_GroES-like
IPR002085 - ADH_SF_Zn-type
IPR011032 - GroES-like
IPR016040 - NAD(P)-bd_dom
IPR002364 - Quin_OxRdtase/zeta-crystal_CS

Pfam Domains:
PF00107 - Zinc-binding dehydrogenase
PF08240 - Alcohol dehydrogenase GroES-like domain
PF13602 - Zinc-binding dehydrogenase

SCOP Domains:
50129 - GroES-like
51366 - Ribulose-phoshate binding barrel
51556 - Metallo-dependent hydrolases
51735 - NAD(P)-binding Rossmann-fold domains
52210 - Succinyl-CoA synthetase domains
51984 - MurCD N-terminal domain
53335 - S-adenosyl-L-methionine-dependent methyltransferases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1YB5 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q08257
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0003960 NADPH:quinone reductase activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0070402 NADPH binding
GO:0070404 NADH binding

Biological Process:
GO:0007601 visual perception
GO:0042178 xenobiotic catabolic process
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BX649061 - Homo sapiens mRNA; cDNA DKFZp779E0834 (from clone DKFZp779E0834).
BC039578 - Homo sapiens crystallin, zeta (quinone reductase), mRNA (cDNA clone MGC:48707 IMAGE:6067125), complete cds.
BC070058 - Homo sapiens crystallin, zeta (quinone reductase), mRNA (cDNA clone MGC:87228 IMAGE:5267616), complete cds.
GQ891423 - Homo sapiens clone HEL-S-144 epididymis secretory sperm binding protein mRNA, complete cds.
LF383842 - JP 2014500723-A/191345: Polycomb-Associated Non-Coding RNAs.
AK123469 - Homo sapiens cDNA FLJ41475 fis, clone BRTHA2001812, highly similar to Homo sapiens zeta-crystallin/quinone reductase mRNA.
AK128794 - Homo sapiens cDNA FLJ45484 fis, clone BRTHA2002512, highly similar to Quinone oxidoreductase (EC 1.6.5.5).
BX647883 - Homo sapiens mRNA; cDNA DKFZp686C16101 (from clone DKFZp686C16101).
L13278 - Homo sapiens zeta-crystallin/quinone reductase mRNA, complete cds.
AK223150 - Homo sapiens mRNA for crystallin, zeta variant, clone: LNG00686.
LF353689 - JP 2014500723-A/161192: Polycomb-Associated Non-Coding RNAs.
AK223201 - Homo sapiens mRNA for crystallin, zeta variant, clone: REC05732.
JD564070 - Sequence 545094 from Patent EP1572962.
JD047054 - Sequence 28078 from Patent EP1572962.
AB209714 - Homo sapiens mRNA for crystallin, zeta variant protein.
JD299651 - Sequence 280675 from Patent EP1572962.
LF353688 - JP 2014500723-A/161191: Polycomb-Associated Non-Coding RNAs.
JD556879 - Sequence 537903 from Patent EP1572962.
JD563904 - Sequence 544928 from Patent EP1572962.
JD229176 - Sequence 210200 from Patent EP1572962.
AK314813 - Homo sapiens cDNA, FLJ95689.
KJ896654 - Synthetic construct Homo sapiens clone ccsbBroadEn_06048 CRYZ gene, encodes complete protein.
AB529134 - Synthetic construct DNA, clone: pF1KB5023, Homo sapiens CRYZ gene for crystallin, zeta, without stop codon, in Flexi system.
LF353687 - JP 2014500723-A/161190: Polycomb-Associated Non-Coding RNAs.
LF353684 - JP 2014500723-A/161187: Polycomb-Associated Non-Coding RNAs.
MA619419 - JP 2018138019-A/191345: Polycomb-Associated Non-Coding RNAs.
MA589266 - JP 2018138019-A/161192: Polycomb-Associated Non-Coding RNAs.
MA589265 - JP 2018138019-A/161191: Polycomb-Associated Non-Coding RNAs.
MA589264 - JP 2018138019-A/161190: Polycomb-Associated Non-Coding RNAs.
MA589261 - JP 2018138019-A/161187: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_arenrf2Pathway - Oxidative Stress Induced Gene Expression Via Nrf2

-  Other Names for This Gene
  Alternate Gene Symbols: A6NN60, D3DQ76, ENST00000340866.1, ENST00000340866.2, ENST00000340866.3, ENST00000340866.4, ENST00000340866.5, ENST00000340866.6, ENST00000340866.7, ENST00000340866.8, ENST00000340866.9, NM_001889, Q08257, Q53FT0, Q59EU7, Q5HYE7, Q6NSK9, QOR_HUMAN, uc317vvd.1, uc317vvd.2
UCSC ID: ENST00000340866.10_7
RefSeq Accession: NM_001889.4
Protein: Q08257 (aka QOR_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.