Human Gene CRHBP (ENST00000274368.9_4) from GENCODE V47lift37
  Description: corticotropin releasing hormone binding protein (from RefSeq NM_001882.4)
Gencode Transcript: ENST00000274368.9_4
Gencode Gene: ENSG00000145708.11_7
Transcript (Including UTRs)
   Position: hg19 chr5:76,248,870-76,265,296 Size: 16,427 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr5:76,248,960-76,264,710 Size: 15,751 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:76,248,870-76,265,296)mRNA (may differ from genome)Protein (322 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CRHBP_HUMAN
DESCRIPTION: RecName: Full=Corticotropin-releasing factor-binding protein; Short=CRF-BP; Short=CRF-binding protein; AltName: Full=Corticotropin-releasing hormone-binding protein; Short=CRH-BP; Flags: Precursor;
FUNCTION: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the CRF-binding protein family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.55 RPKM in Spleen
Total median expression: 89.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.0090-0.311 Picture PostScript Text
3' UTR -124.10586-0.212 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008435 - CRF-bd
IPR000859 - CUB

Pfam Domains:
PF05428 - Corticotropin-releasing factor binding protein (CRF-BP)

SCOP Domains:
49854 - Spermadhesin, CUB domain

ModBase Predicted Comparative 3D Structure on P24387
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0042277 peptide binding
GO:0051424 corticotropin-releasing hormone binding

Biological Process:
GO:0001963 synaptic transmission, dopaminergic
GO:0002125 maternal aggressive behavior
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007565 female pregnancy
GO:0007611 learning or memory
GO:0009755 hormone-mediated signaling pathway
GO:0035690 cellular response to drug
GO:0035865 cellular response to potassium ion
GO:0042445 hormone metabolic process
GO:0045055 regulated exocytosis
GO:0048149 behavioral response to ethanol
GO:0051459 regulation of corticotropin secretion
GO:0051460 negative regulation of corticotropin secretion
GO:0071277 cellular response to calcium ion
GO:0071314 cellular response to cocaine
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor
GO:0071391 cellular response to estrogen stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0080135 regulation of cellular response to stress
GO:0097211 cellular response to gonadotropin-releasing hormone
GO:1900011 negative regulation of corticotropin-releasing hormone receptor activity
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005767 secondary lysosome
GO:0005771 multivesicular body
GO:0005874 microtubule
GO:0030141 secretory granule
GO:0030425 dendrite
GO:0031045 dense core granule
GO:0043196 varicosity
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus


-  Descriptions from all associated GenBank mRNAs
  AK223457 - Homo sapiens mRNA for corticotropin releasing hormone binding protein variant, clone: FCC115E06.
AK307729 - Homo sapiens cDNA, FLJ97677.
BC018038 - Homo sapiens corticotropin releasing hormone binding protein, mRNA (cDNA clone MGC:26246 IMAGE:4812893), complete cds.
AK311052 - Homo sapiens cDNA, FLJ18094.
JD423153 - Sequence 404177 from Patent EP1572962.
JD457093 - Sequence 438117 from Patent EP1572962.
X58022 - Human mRNA for corticotropin-releasing factor binding protein (CRF-BP).
CU676144 - Synthetic construct Homo sapiens gateway clone IMAGE:100018909 5' read CRHBP mRNA.
HQ447855 - Synthetic construct Homo sapiens clone IMAGE:100071199; CCSB001253_01 corticotropin releasing hormone binding protein (CRHBP) gene, encodes complete protein.
KJ890968 - Synthetic construct Homo sapiens clone ccsbBroadEn_00362 CRHBP gene, encodes complete protein.
CR541666 - Homo sapiens full open reading frame cDNA clone RZPDo834H0627D for gene CRHBP, corticotropin releasing hormone binding protein; complete cds, incl. stopcodon.
JD098943 - Sequence 79967 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P24387 (Reactome details) participates in the following event(s):

R-HSA-8937613 CRHBP binds CRH
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: CRFBP, CRHBP_HUMAN, ENST00000274368.1, ENST00000274368.2, ENST00000274368.3, ENST00000274368.4, ENST00000274368.5, ENST00000274368.6, ENST00000274368.7, ENST00000274368.8, NM_001882, P24387, Q53F32, Q6FHT5, uc317jev.1, uc317jev.2
UCSC ID: ENST00000274368.9_4
RefSeq Accession: NM_001882.4
Protein: P24387 (aka CRHBP_HUMAN or CRFB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.