ID:ZHANG_HUMAN DESCRIPTION: RecName: Full=CREB/ATF bZIP transcription factor; AltName: Full=Host cell factor-binding transcription factor Zhangfei; Short=HCF-binding transcription factor Zhangfei; FUNCTION: Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1- dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. SUBUNIT: Interacts with HCFC1; the interaction inhibits CREB3 transcriptional activity. INTERACTION: P62509:Esrrg (xeno); NbExp=3; IntAct=EBI-632965, EBI-5274019; P51610:HCFC1; NbExp=8; IntAct=EBI-632965, EBI-396176; Q96EB6:SIRT1; NbExp=3; IntAct=EBI-632965, EBI-1802965; SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1. TISSUE SPECIFICITY: In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver. MISCELLANEOUS: Named 'Zhangfei' after a legendary Chinese warrior who was contemporary with Luman in around 220 AD. SIMILARITY: Belongs to the bZIP family. ATF subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. SEQUENCE CAUTION: Sequence=AAD28325.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD28325.1; Type=Frameshift; Positions=5, 49; Sequence=AAZ42189.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG36256.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG36256.1; Type=Frameshift; Positions=59;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NS37
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0009615 response to virus GO:0045814 negative regulation of gene expression, epigenetic GO:0045892 negative regulation of transcription, DNA-templated GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
