Human Gene CR1 (ENST00000367049.9_8) from GENCODE V47lift37

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Description: complement C3b/C4b receptor 1 (Knops blood group), transcript variant S (from RefSeq NM_000651.6)
Gencode Transcript: ENST00000367049.9_8
Gencode Gene: ENSG00000203710.12_15
Transcript (Including UTRs)
Position: hg19 chr1:207,669,502-207,815,110 Size: 145,609 Total Exon Count: 47 Strand: +
Coding Region
Position: hg19 chr1:207,669,613-207,812,754 Size: 143,142 Coding Exon Count: 47

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:207,669,502-207,815,110)			mRNA (may differ from genome)		Protein (2489 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: E9PDY4_HUMAN DESCRIPTION: SubName: Full=Complement receptor type 1; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: CR1 Diseases sorted by gene-association score: malaria* (359), plasmodium falciparum malaria (41), follicular dendritic cell sarcoma (24), glomerulonephritis (13), systemic lupus erythematosus (13), histiocytic and dendritic cell cancer (12), alzheimer disease risk factor (12), complement factor i deficiency (11), parapharyngeal meningioma (11), viral pneumonia (10), dendritic cell tumor (10), arthus reaction (9), thyroid crisis (8), proliferative glomerulonephritis (8), castleman disease (8), interdigitating dendritic cell sarcoma (8), t-cell/histiocyte rich large b cell lymphoma (7), hemoglobinuria (7), variola minor (7), follicular lymphoma (6), inflammatory myofibroblastic tumor (6), reticulum cell sarcoma (6), langerhans cell sarcoma (6), afibrinogenemia, congenital (5), afibrinogenemia (5), lateral medullary syndrome (5), histiocytic sarcoma (5), mycetoma (5), hemophagocytic lymphohistiocytosis (2), leukemia, acute myeloid (1) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004397 Fonofos D006493 Heparin D006861 Hydrogen Peroxide D015570 Josamycin D008345 Manganese D010278 Parathion D011692 Puromycin Aminonucleoside C034206 Ribomunyl D015032 Zinc C025340 manganese chloride more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 16.50 RPKM in Whole Blood Total median expression: 47.20 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-23.40	111	-0.211	Picture	PostScript	Text
3' UTR	-566.50	2356	-0.240	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR016060 - Complement_control_module
IPR000436 - Sushi_SCR_CCP

Pfam Domains:
PF00084 - Sushi repeat (SCR repeat)

SCOP Domains:
50370 - Ricin B-like lectins
101908 - Putative isomerase YbhE
50978 - WD40 repeat-like
69635 - Type III secretory system chaperone-like
55287 - RPB5-like RNA polymerase subunit
57535 - Complement control module/SCR domain
57196 - EGF/Laminin

ModBase Predicted Comparative 3D Structure on E9PDY4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	LP895160 - Sequence 24 from Patent EP3253886. LP895735 - Sequence 599 from Patent EP3253886. Y00816 - Human mRNA for complement receptor type 1 (CR1, C3b/C4b receptor, CD35). BC032550 - Homo sapiens cDNA clone IMAGE:5554371. X05309 - Human mRNA for C3b/C4b receptor (CR1) F allotype. AK309342 - Homo sapiens cDNA, FLJ99383. JD521180 - Sequence 502204 from Patent EP1572962. AK298486 - Homo sapiens cDNA FLJ57885 complete cds, highly similar to Complement receptor type 1 precursor. X14362 - Human CR1 mRNA for C3b/C4b receptor secreted form. JD127331 - Sequence 108355 from Patent EP1572962. JD355830 - Sequence 336854 from Patent EP1572962. JD221215 - Sequence 202239 from Patent EP1572962. JD127331 - Sequence 108355 from Patent EP1572962. JD355830 - Sequence 336854 from Patent EP1572962. JD221215 - Sequence 202239 from Patent EP1572962. AH002679 - Homo sapiens CR1 receptor (CR1) mRNA, partial cds. JD127331 - Sequence 108355 from Patent EP1572962. JD355830 - Sequence 336854 from Patent EP1572962. JD221215 - Sequence 202239 from Patent EP1572962. JD528349 - Sequence 509373 from Patent EP1572962. JD365397 - Sequence 346421 from Patent EP1572962. JD355830 - Sequence 336854 from Patent EP1572962. JD221215 - Sequence 202239 from Patent EP1572962. JD127331 - Sequence 108355 from Patent EP1572962. JD365397 - Sequence 346421 from Patent EP1572962. JD355830 - Sequence 336854 from Patent EP1572962. JD221215 - Sequence 202239 from Patent EP1572962. JD508090 - Sequence 489114 from Patent EP1572962. JD068780 - Sequence 49804 from Patent EP1572962. JD227368 - Sequence 208392 from Patent EP1572962. JD316887 - Sequence 297911 from Patent EP1572962. JD310754 - Sequence 291778 from Patent EP1572962. JD502471 - Sequence 483495 from Patent EP1572962. JD374987 - Sequence 356011 from Patent EP1572962. JD284174 - Sequence 265198 from Patent EP1572962. JD374760 - Sequence 355784 from Patent EP1572962. JD346302 - Sequence 327326 from Patent EP1572962. JD226846 - Sequence 207870 from Patent EP1572962. JD519148 - Sequence 500172 from Patent EP1572962. JD409349 - Sequence 390373 from Patent EP1572962. JD545293 - Sequence 526317 from Patent EP1572962. JD173843 - Sequence 154867 from Patent EP1572962. JD333135 - Sequence 314159 from Patent EP1572962. JD058781 - Sequence 39805 from Patent EP1572962. JD318052 - Sequence 299076 from Patent EP1572962. JD256537 - Sequence 237561 from Patent EP1572962. JD560687 - Sequence 541711 from Patent EP1572962. JD476721 - Sequence 457745 from Patent EP1572962. JD397043 - Sequence 378067 from Patent EP1572962. JD414790 - Sequence 395814 from Patent EP1572962. JD414791 - Sequence 395815 from Patent EP1572962. JD414792 - Sequence 395816 from Patent EP1572962. JD120549 - Sequence 101573 from Patent EP1572962. JD120550 - Sequence 101574 from Patent EP1572962. JD379644 - Sequence 360668 from Patent EP1572962. JD379645 - Sequence 360669 from Patent EP1572962. JD379646 - Sequence 360670 from Patent EP1572962. JD094107 - Sequence 75131 from Patent EP1572962. JD106881 - Sequence 87905 from Patent EP1572962. JD553879 - Sequence 534903 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_blymphocytePathway - B Lymphocyte Cell Surface Molecules

Other Names for This Gene


	Alternate Gene Symbols: CR1 , E9PDY4, E9PDY4_HUMAN, ENST00000367049.1, ENST00000367049.2, ENST00000367049.3, ENST00000367049.4, ENST00000367049.5, ENST00000367049.6, ENST00000367049.7, ENST00000367049.8, NM_000651, uc318fox.1, uc318fox.2 UCSC ID: ENST00000367049.9_8 RefSeq Accession: NM_000651.6 Protein: E9PDY4

Gene Model Information


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Methods, Credits, and Use Restrictions


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