ID:CBPB2_HUMAN DESCRIPTION: RecName: Full=Carboxypeptidase B2; EC=3.4.17.20; AltName: Full=Carboxypeptidase U; Short=CPU; AltName: Full=Plasma carboxypeptidase B; Short=pCPB; AltName: Full=Thrombin-activable fibrinolysis inhibitor; Short=TAFI; Flags: Precursor; FUNCTION: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. CATALYTIC ACTIVITY: Release of C-terminal Arg and Lys from a polypeptide. COFACTOR: Binds 1 zinc ion per subunit. ENZYME REGULATION: TAFI/CPB2 is unique among carboxypeptidases in that it spontaneously inactivates with a short half-life, a property that is crucial for its role in controlling blood clot lysis. The zymogen is stabilized by interactions with the activation peptide. Release of the activation peptide increases a dynamic flap mobility and in time this leads to conformational changes that disrupt the catalytic site and expose a cryptic thrombin-cleavage site present at Arg-324. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Plasma; synthesized in the liver. PTM: N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4. SIMILARITY: Belongs to the peptidase M14 family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cpb2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96IY4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
