ID:COASY_HUMAN DESCRIPTION: RecName: Full=Bifunctional coenzyme A synthase; Short=CoA synthase; AltName: Full=NBP; AltName: Full=POV-2; Includes: RecName: Full=Phosphopantetheine adenylyltransferase; EC=2.7.7.3; AltName: Full=Dephospho-CoA pyrophosphorylase; AltName: Full=Pantetheine-phosphate adenylyltransferase; Short=PPAT; Includes: RecName: Full=Dephospho-CoA kinase; Short=DPCK; EC=2.7.1.24; AltName: Full=Dephosphocoenzyme A kinase; Short=DPCOAK; FUNCTION: Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. CATALYTIC ACTIVITY: ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. CATALYTIC ACTIVITY: ATP + 3'-dephospho-CoA = ADP + CoA. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=7.6 mM for 4'-phoshopantetheine; KM=145 mM for ATP (in the PPAT reaction); KM=16.7 mM for dephospho-CoA; KM=34.4 mM for ATP (in the DPCK reaction); PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. SIMILARITY: In the central section; belongs to the eukaryotic coaD family. SIMILARITY: Contains 1 DPCK (dephospho-CoA kinase) domain. SEQUENCE CAUTION: Sequence=AAA69699.1; Type=Frameshift; Positions=535; Sequence=AAF87955.1; Type=Erroneous initiation; Sequence=AAH06354.1; Type=Erroneous initiation; Sequence=AAH20985.1; Type=Erroneous initiation; Sequence=AK075415; Type=Frameshift; Positions=315;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13057
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.