ID:CNTRB_HUMAN DESCRIPTION: RecName: Full=Centrobin; AltName: Full=Centrosomal BRCA2-interacting protein; AltName: Full=LYST-interacting protein 8; FUNCTION: Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis. SUBUNIT: Interacts with LYST. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole. TISSUE SPECIFICITY: Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. DEVELOPMENTAL STAGE: Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE CAUTION: Sequence=AAG49447.1; Type=Erroneous translation; Note=Wrong choice of frame; Sequence=AAG49447.1; Type=Frameshift; Positions=609; Sequence=BAC11241.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q8N137
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
