ID:CNTN2_HUMAN DESCRIPTION: RecName: Full=Contactin-2; AltName: Full=Axonal glycoprotein TAG-1; AltName: Full=Axonin-1; AltName: Full=Transient axonal glycoprotein 1; Short=TAX-1; Flags: Precursor; FUNCTION: May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the neuronal membrane by a GPI-anchor and is also released from neurons. SIMILARITY: Belongs to the immunoglobulin superfamily. Contactin family. SIMILARITY: Contains 4 fibronectin type-III domains. SIMILARITY: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02246
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0030246 carbohydrate binding GO:0042802 identical protein binding GO:0043621 protein self-association
Biological Process: GO:0000226 microtubule cytoskeleton organization GO:0001764 neuron migration GO:0007155 cell adhesion GO:0007399 nervous system development GO:0007411 axon guidance GO:0007413 axonal fasciculation GO:0007612 learning GO:0007628 adult walking behavior GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010954 positive regulation of protein processing GO:0021853 cerebral cortex GABAergic interneuron migration GO:0022010 central nervous system myelination GO:0031133 regulation of axon diameter GO:0031175 neuron projection development GO:0031623 receptor internalization GO:0045163 clustering of voltage-gated potassium channels GO:0045665 negative regulation of neuron differentiation GO:0048168 regulation of neuronal synaptic plasticity GO:0048710 regulation of astrocyte differentiation GO:0060168 positive regulation of adenosine receptor signaling pathway GO:0071205 protein localization to juxtaparanode region of axon GO:0071206 establishment of protein localization to juxtaparanode region of axon GO:0097090 presynaptic membrane organization
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
