Human Gene CNOT10 (ENST00000328834.10_7) from GENCODE V47lift37

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Description: CCR4-NOT transcription complex subunit 10, transcript variant 1 (from RefSeq NM_015442.3)
Gencode Transcript: ENST00000328834.10_7
Gencode Gene: ENSG00000182973.20_11
Transcript (Including UTRs)
Position: hg19 chr3:32,726,680-32,815,367 Size: 88,688 Total Exon Count: 19 Strand: +
Coding Region
Position: hg19 chr3:32,726,953-32,815,103 Size: 88,151 Coding Exon Count: 19

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:32,726,680-32,815,367)			mRNA (may differ from genome)		Protein (744 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	Reactome	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: CNOTA_HUMAN DESCRIPTION: RecName: Full=CCR4-NOT transcription complex subunit 10; SUBUNIT: Component of the CCR4-NOT complex at least composed of CNOT1, CNOT2, CNOT3, CNOT8, CNOT9, CNOT10 and TNKS1BP1 (By similarity). INTERACTION: Q9ULM6:CNOT6; NbExp=1; IntAct=EBI-1054261, EBI-2104530; Q96LI5:CNOT6L; NbExp=1; IntAct=EBI-1054261, EBI-1046635; Q9UFF9:CNOT8; NbExp=1; IntAct=EBI-1054261, EBI-742299; P50616:TOB1; NbExp=1; IntAct=EBI-1054261, EBI-723281; SIMILARITY: Belongs to the CNOT10 family. SEQUENCE CAUTION: Sequence=BAB13876.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene D000082 Acetaminophen D001564 Benzo(a)pyrene D019256 Cadmium Chloride D020111 Chlorodiphenyl (54% Chlorine) D016572 Cyclosporine D007657 Ketone Bodies D013749 Tetrachlorodibenzodioxin C006780 bisphenol A C009277 sodium arsenate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 18.59 RPKM in Testis Total median expression: 252.42 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-127.40	273	-0.467	Picture	PostScript	Text
3' UTR	-55.20	264	-0.209	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001440 - TPR-1
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

Pfam Domains:
PF13176 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
63570 - PABC (PABP) domain

ModBase Predicted Comparative 3D Structure on Q9H9A5


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006417 regulation of translation GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0031047 gene silencing by RNA Cellular Component: GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol GO:0016020 membrane GO:0030014 CCR4-NOT complex

Descriptions from all associated GenBank mRNAs


	AK023227 - Homo sapiens cDNA FLJ13165 fis, clone NT2RP3003686. AK022952 - Homo sapiens cDNA FLJ12890 fis, clone NT2RP2004124. LF384602 - JP 2014500723-A/192105: Polycomb-Associated Non-Coding RNAs. AK309670 - Homo sapiens cDNA, FLJ99711. BC006382 - Homo sapiens cDNA clone IMAGE:4099860, containing frame-shift errors. BC002931 - Homo sapiens CCR4-NOT transcription complex, subunit 10, mRNA (cDNA clone MGC:11369 IMAGE:3955575), complete cds. BC002928 - Homo sapiens CCR4-NOT transcription complex, subunit 10, mRNA (cDNA clone MGC:11357 IMAGE:3954507), complete cds. AK297085 - Homo sapiens cDNA FLJ60672 complete cds, highly similar to Homo sapiens CCR4-NOT transcription complex, subunit 10 (CNOT10), mRNA. AK298693 - Homo sapiens cDNA FLJ61333 complete cds, highly similar to Homo sapiens CCR4-NOT transcription complex, subunit 10 (CNOT10), mRNA. AK022576 - Homo sapiens cDNA FLJ12514 fis, clone NT2RM2001768. EU831581 - Synthetic construct Homo sapiens clone HAIB:100066610; DKFZo004H1218 CCR4-NOT transcription complex, subunit 10 protein (CNOT10) gene, encodes complete protein. DQ892895 - Synthetic construct clone IMAGE:100005525; FLH191782.01X; RZPDo839G1177D CCR4-NOT transcription complex, subunit 10 (CNOT10) gene, encodes complete protein. DQ896143 - Synthetic construct Homo sapiens clone IMAGE:100010603; FLH191778.01L; RZPDo839G1167D CCR4-NOT transcription complex, subunit 10 (CNOT10) gene, encodes complete protein. KJ906105 - Synthetic construct Homo sapiens clone ccsbBroadEn_15775 CNOT10 gene, encodes complete protein. EU831494 - Synthetic construct Homo sapiens clone HAIB:100066523; DKFZo008H1217 CCR4-NOT transcription complex, subunit 10 protein (CNOT10) gene, encodes complete protein. KJ898568 - Synthetic construct Homo sapiens clone ccsbBroadEn_07962 CNOT10 gene, encodes complete protein. AK302196 - Homo sapiens cDNA FLJ56488 complete cds, highly similar to Homo sapiens CCR4-NOT transcription complex, subunit 10 (CNOT10), mRNA. AK027026 - Homo sapiens cDNA: FLJ23373 fis, clone HEP16118. AK021695 - Homo sapiens cDNA FLJ11633 fis, clone HEMBA1004274. MA620179 - JP 2018138019-A/192105: Polycomb-Associated Non-Coding RNAs. JD278645 - Sequence 259669 from Patent EP1572962. JD406216 - Sequence 387240 from Patent EP1572962. JD041655 - Sequence 22679 from Patent EP1572962. JD436566 - Sequence 417590 from Patent EP1572962. CU678298 - Synthetic construct Homo sapiens gateway clone IMAGE:100017480 5' read CNOT10 mRNA. CU678296 - Synthetic construct Homo sapiens gateway clone IMAGE:100017782 5' read CNOT10 mRNA. DQ597677 - Homo sapiens piRNA piR-35743, complete sequence. AL117639 - Homo sapiens mRNA; cDNA DKFZp434K115 (from clone DKFZp434K115). JD023765 - Sequence 4789 from Patent EP1572962. JD029483 - Sequence 10507 from Patent EP1572962. JD456362 - Sequence 437386 from Patent EP1572962. JD180431 - Sequence 161455 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9H9A5 (Reactome details) participates in the following event(s): R-HSA-6798044 BTG2 binds CCR4-NOT complex R-HSA-429955 CCR4-NOT complex deadenylates mRNA R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-429947 Deadenylation of mRNA R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-429914 Deadenylation-dependent mRNA decay R-HSA-212436 Generic Transcription Pathway R-HSA-8953854 Metabolism of RNA R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: B7Z7L1, CNO10_HUMAN, ENST00000328834.1, ENST00000328834.2, ENST00000328834.3, ENST00000328834.4, ENST00000328834.5, ENST00000328834.6, ENST00000328834.7, ENST00000328834.8, ENST00000328834.9, F8WAF2, NM_015442, Q9BU30, Q9H5J7, Q9H8X1, Q9H9A5, Q9H9W0, Q9HAH3, Q9UFJ2, uc317spa.1, uc317spa.2 UCSC ID: ENST00000328834.10_7 RefSeq Accession: NM_015442.3 Protein: Q9H9A5 (aka CNOTA_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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