ID:CLIC2_HUMAN DESCRIPTION: RecName: Full=Chloride intracellular channel protein 2; AltName: Full=XAP121; FUNCTION: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. SUBUNIT: Monomer. Interacts with TRAPPC2 and RYR2. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Single-pass membrane protein (Probable). Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. TISSUE SPECIFICITY: Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in adult stomach and testis. Expressed in fetal thymus and kidney. DOMAIN: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion. DISEASE: Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure. SIMILARITY: Belongs to the chloride channel CLIC family. SIMILARITY: Contains 1 GST C-terminal domain. SEQUENCE CAUTION: Sequence=CAA73228.1; Type=Frameshift; Positions=244;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15247
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006821 chloride transport GO:0007165 signal transduction GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0034765 regulation of ion transmembrane transport GO:0051099 positive regulation of binding GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0098869 cellular oxidant detoxification GO:1902476 chloride transmembrane transport GO:0006749 glutathione metabolic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
