Human Gene CKS2 (ENST00000314355.7_4) from GENCODE V47lift37
  Description: CDC28 protein kinase regulatory subunit 2 (from RefSeq NM_001827.3)
Gencode Transcript: ENST00000314355.7_4
Gencode Gene: ENSG00000123975.5_7
Transcript (Including UTRs)
   Position: hg19 chr9:91,926,110-91,931,618 Size: 5,509 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr9:91,926,208-91,931,340 Size: 5,133 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:91,926,110-91,931,618)mRNA (may differ from genome)Protein (79 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CKS2_HUMAN
DESCRIPTION: RecName: Full=Cyclin-dependent kinases regulatory subunit 2; Short=CKS-2;
FUNCTION: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
SUBUNIT: Forms a homohexamer that can probably bind six kinase subunits.
SIMILARITY: Belongs to the CKS family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cks2/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 159.35 RPKM in Testis
Total median expression: 632.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.0098-0.306 Picture PostScript Text
3' UTR -53.60278-0.193 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000789 - Cyclin-dep_kinase_reg-sub

Pfam Domains:
PF01111 - Cyclin-dependent kinase regulatory subunit

SCOP Domains:
55637 - Cell cycle regulatory proteins

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1CKS - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P33552
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901 protein kinase binding
GO:0042393 histone binding
GO:0043130 ubiquitin binding
GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007049 cell cycle
GO:0007127 meiosis I
GO:0007346 regulation of mitotic cell cycle
GO:0008283 cell proliferation
GO:0044772 mitotic cell cycle phase transition
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051301 cell division

Cellular Component:
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0019005 SCF ubiquitin ligase complex


-  Descriptions from all associated GenBank mRNAs
  X54942 - H.sapiens ckshs2 mRNA for Cks1 protein homologue.
BC006458 - Homo sapiens CDC28 protein kinase regulatory subunit 2, mRNA (cDNA clone MGC:1779 IMAGE:3538689), complete cds.
DM107444 - METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL.
HW120448 - JP 2013049691-A/3: METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL.
LF858551 - JP 2015172074-A/3: METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL.
CR407630 - Homo sapiens full open reading frame cDNA clone RZPDo834G0216D for gene CKS2, CDC28 protein kinase regulatory subunit 2 complete cds, without stopcodon.
AB527990 - Synthetic construct DNA, clone: pF1KB6707, Homo sapiens CKS2 gene for CDC28 protein kinase regulatory subunit 2, without stop codon, in Flexi system.
BT006630 - Homo sapiens CDC28 protein kinase regulatory subunit 2 mRNA, complete cds.
KJ890923 - Synthetic construct Homo sapiens clone ccsbBroadEn_00317 CKS2 gene, encodes complete protein.
KJ905176 - Synthetic construct Homo sapiens clone ccsbBroadEn_14588 CKS2 gene, encodes complete protein.
CR542118 - Homo sapiens full open reading frame cDNA clone RZPDo834A0223D for gene CKS2, CDC28 protein kinase regulatory subunit 2; complete cds, incl. stopcodon.
JD466984 - Sequence 448008 from Patent EP1572962.
JD358621 - Sequence 339645 from Patent EP1572962.
MA725901 - JP 2017114907-A/3: METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL.

-  Other Names for This Gene
  Alternate Gene Symbols: CKS2_HUMAN, ENST00000314355.1, ENST00000314355.2, ENST00000314355.3, ENST00000314355.4, ENST00000314355.5, ENST00000314355.6, NM_001827, P33552, Q6FGI9, Q6LET5, uc317ppl.1, uc317ppl.2
UCSC ID: ENST00000314355.7_4
RefSeq Accession: NM_001827.3
Protein: P33552 (aka CKS2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.