ID:CEP63_HUMAN DESCRIPTION: RecName: Full=Centrosomal protein of 63 kDa; Short=Cep63; FUNCTION: Required for normal spindle assembly. Maintains centrosome numbers through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). SUBUNIT: Interacts with CEP152 and CDK1; these interactions recruit both ligands to centrosomes. May also interact with CDK2. INTERACTION: Q9NRI5:DISC1; NbExp=7; IntAct=EBI-741977, EBI-529989; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with CEP152 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. DISEASE: Defects in CEP63 are the cause of Seckel syndrome type 6 (SCKL6) [MIM:614728]. A rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation. SIMILARITY: Belongs to the CEP63 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF17045 - Centrosomal protein of 63 kDa
ModBase Predicted Comparative 3D Structure on Q96MT8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000077 DNA damage checkpoint GO:0000086 G2/M transition of mitotic cell cycle GO:0006974 cellular response to DNA damage stimulus GO:0007049 cell cycle GO:0007099 centriole replication GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0042770 signal transduction in response to DNA damage GO:0051225 spindle assembly GO:0051301 cell division GO:0097711 ciliary basal body docking GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
BC014050 - Homo sapiens centrosomal protein 63kDa, mRNA (cDNA clone MGC:19876 IMAGE:3639744), complete cds. AK023738 - Homo sapiens cDNA FLJ13676 fis, clone PLACE1011922, weakly similar to MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B. AK023448 - Homo sapiens cDNA FLJ13386 fis, clone PLACE1001104, weakly similar to MYOSIN HEAVY CHAIN, NON-MUSCLE. BC068997 - Homo sapiens centrosomal protein 63kDa, mRNA (cDNA clone MGC:78416 IMAGE:5951988), complete cds. AK056465 - Homo sapiens cDNA FLJ31903 fis, clone NT2RP7004260, weakly similar to MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B. HQ447283 - Synthetic construct Homo sapiens clone IMAGE:100070594; CCSB007011_02 centrosomal protein 63kDa (CEP63) gene, encodes complete protein. KJ894801 - Synthetic construct Homo sapiens clone ccsbBroadEn_04195 CEP63 gene, encodes complete protein. CU680758 - Synthetic construct Homo sapiens gateway clone IMAGE:100019672 5' read CEP63 mRNA. JD049110 - Sequence 30134 from Patent EP1572962. AK054897 - Homo sapiens cDNA FLJ30335 fis, clone BRACE2007281. JD304731 - Sequence 285755 from Patent EP1572962. JD204260 - Sequence 185284 from Patent EP1572962. AK123837 - Homo sapiens cDNA FLJ41843 fis, clone NT2RI3003027. DQ571424 - Homo sapiens piRNA piR-31536, complete sequence. JD353168 - Sequence 334192 from Patent EP1572962. JD218228 - Sequence 199252 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96MT8 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
