ID:AZI1_HUMAN DESCRIPTION: RecName: Full=5-azacytidine-induced protein 1; AltName: Full=Centrosomal protein of 131 kDa; Short=Cep131; AltName: Full=Pre-acrosome localization protein 1; FUNCTION: May play a role in spermatogenesis (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 IQ domain. SEQUENCE CAUTION: Sequence=BAA83070.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9UPN4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0042803 protein homodimerization activity GO:0044877 macromolecular complex binding
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0007049 cell cycle GO:0007275 multicellular organism development GO:0007283 spermatogenesis GO:0008284 positive regulation of cell proliferation GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0010824 regulation of centrosome duplication GO:0030030 cell projection organization GO:0030154 cell differentiation GO:0035735 intraciliary transport involved in cilium assembly GO:0071539 protein localization to centrosome GO:0090316 positive regulation of intracellular protein transport GO:0097711 ciliary basal body docking
AB029041 - Homo sapiens KIAA1118 mRNA for KIAA1118 protein. BC010413 - Homo sapiens 5-azacytidine induced 1, mRNA (cDNA clone IMAGE:3841026), partial cds. BC011615 - Homo sapiens 5-azacytidine induced 1, mRNA (cDNA clone IMAGE:3945607), partial cds. BC012130 - Homo sapiens 5-azacytidine induced 1, mRNA (cDNA clone IMAGE:4634709), with apparent retained intron. BC136578 - Homo sapiens 5-azacytidine induced 1, mRNA (cDNA clone MGC:168191 IMAGE:9020568), complete cds. BC136580 - Homo sapiens 5-azacytidine induced 1, mRNA (cDNA clone MGC:168193 IMAGE:9020570), complete cds. BC144263 - Homo sapiens cDNA clone IMAGE:9052783, containing frame-shift errors. BC040023 - Homo sapiens 5-azacytidine induced 1, mRNA (cDNA clone IMAGE:4151393), with apparent retained intron. JD173745 - Sequence 154769 from Patent EP1572962. JD539921 - Sequence 520945 from Patent EP1572962. JD435160 - Sequence 416184 from Patent EP1572962. JD269944 - Sequence 250968 from Patent EP1572962. JD520563 - Sequence 501587 from Patent EP1572962. JD508748 - Sequence 489772 from Patent EP1572962. JD489879 - Sequence 470903 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UPN4 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
