Human Gene CD33 (ENST00000262262.5_8) from GENCODE V47lift37

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Description: CD33 molecule, transcript variant 1 (from RefSeq NM_001772.4)
Gencode Transcript: ENST00000262262.5_8
Gencode Gene: ENSG00000105383.15_11
Transcript (Including UTRs)
Position: hg19 chr19:51,728,336-51,743,271 Size: 14,936 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr19:51,728,375-51,742,943 Size: 14,569 Coding Exon Count: 7

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:51,728,336-51,743,271)			mRNA (may differ from genome)		Protein (364 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: CD33 Diseases sorted by gene-association score: gallbladder lymphoma (15), extracutaneous mastocytoma (10), nasu-hakola disease (8), leukemia, acute promyelocytic, somatic (7), myeloid leukemia (6), mediastinal cancer (6), aleukemic leukemia cutis (5), myeloproliferative syndrome, transient (5), acute leukemia (5), hepatic vascular disease (4), leukemia, acute myeloid (3), myelodysplastic syndrome (3), leukemia, acute lymphoblastic (2), leukemia, chronic myeloid, somatic (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D006861 Hydrogen Peroxide C043062 N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine D053260 Soot D013806 Theophylline D014028 Tobacco Smoke Pollution D014212 Tretinoin C021751 tanshinone

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 16.57 RPKM in Spleen Total median expression: 75.50 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-8.70	39	-0.223	Picture	PostScript	Text
3' UTR	-81.30	328	-0.248	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set
IPR013151 - Immunoglobulin

Pfam Domains:
PF00047 - Immunoglobulin domain
PF07686 - Immunoglobulin V-set domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on Q546G0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
	Gene Details
	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0005634 nucleus GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	KJ896565 - Synthetic construct Homo sapiens clone ccsbBroadEn_05959 CD33 gene, encodes complete protein. AK293934 - Homo sapiens cDNA FLJ50122 complete cds, highly similar to Myeloid cell surface antigen CD33 precursor. AK309558 - Homo sapiens cDNA, FLJ99599. M23197 - Human differentiation antigen (CD33) mRNA, complete cds. AY162464 - Homo sapiens sialic acid binding immunoglobulin-like lectin 3 (CD33) mRNA, complete cds; alternatively spliced. BC028152 - Homo sapiens CD33 molecule, mRNA (cDNA clone MGC:40026 IMAGE:5217182), complete cds. AK304810 - Homo sapiens cDNA FLJ55411 complete cds, highly similar to Myeloid cell surface antigen CD33 precursor. AB590304 - Synthetic construct DNA, clone: pFN21AE1425, Homo sapiens CD33 gene for CD33 molecule, without stop codon, in Flexi system. DQ891726 - Synthetic construct clone IMAGE:100004356; FLH179448.01X; RZPDo839G08130D CD33 molecule (CD33) gene, encodes complete protein. DQ894903 - Synthetic construct Homo sapiens clone IMAGE:100009363; FLH179444.01L; RZPDo839G08129D CD33 molecule (CD33) gene, encodes complete protein. KX139463 - Homo sapiens isolate APH001 CD33 molecule transcript variant (CD33) mRNA, complete cds. AK090470 - Homo sapiens mRNA for FLJ00391 protein. JD184276 - Sequence 165300 from Patent EP1572962. JD237622 - Sequence 218646 from Patent EP1572962. JD088784 - Sequence 69808 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development

Other Names for This Gene


	Alternate Gene Symbols: CD33 , ENST00000262262.1, ENST00000262262.2, ENST00000262262.3, ENST00000262262.4, hCG_91950 , NM_001772, Q546G0, Q546G0_HUMAN, uc317gyk.1, uc317gyk.2 UCSC ID: ENST00000262262.5_8 RefSeq Accession: NM_001772.4 Protein: Q546G0

Gene Model Information


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Methods, Credits, and Use Restrictions


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