ID:TCPZ_HUMAN DESCRIPTION: RecName: Full=T-complex protein 1 subunit zeta; Short=TCP-1-zeta; AltName: Full=Acute morphine dependence-related protein 2; AltName: Full=CCT-zeta-1; AltName: Full=HTR3; AltName: Full=Tcp20; FUNCTION: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. SUBUNIT: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the TCP-1 chaperonin family. SEQUENCE CAUTION: Sequence=AAA58676.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P40227
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006457 protein folding GO:0006458 'de novo' protein folding GO:0032212 positive regulation of telomere maintenance via telomerase GO:0050821 protein stabilization GO:0061077 chaperone-mediated protein folding GO:1904851 positive regulation of establishment of protein localization to telomere GO:1904871 positive regulation of protein localization to Cajal body GO:1904874 positive regulation of telomerase RNA localization to Cajal body
AB063318 - Homo sapiens MoDP-2, MoDP-3 mRNA for acute morphine dependence related protein 2, acute morphine dependence related peptide 3, complete cds. L27706 - Human chaperonin protein (Tcp20) gene complete cds. BC106941 - Homo sapiens chaperonin containing TCP1, subunit 6A (zeta 1), mRNA (cDNA clone IMAGE:40034020). BC106942 - Homo sapiens chaperonin containing TCP1, subunit 6A (zeta 1), mRNA (cDNA clone MGC:126215 IMAGE:40034021), complete cds. AK316230 - Homo sapiens cDNA, FLJ79129 complete cds, highly similar to T-complex protein 1 subunit zeta. AF385084 - Homo sapiens heat shock protein mRNA, complete cds. AK297751 - Homo sapiens cDNA FLJ53065 complete cds, highly similar to T-complex protein 1 subunit zeta. AK313819 - Homo sapiens cDNA, FLJ94440, highly similar to Homo sapiens chaperonin containing TCP1, subunit 6A (zeta 1)(CCT6A), mRNA. AK298371 - Homo sapiens cDNA FLJ52344 complete cds, highly similar to T-complex protein 1 subunit zeta. AB590066 - Synthetic construct DNA, clone: pFN21AB5054, Homo sapiens CCT6A gene for chaperonin containing TCP1, subunit 6A, without stop codon, in Flexi system. KJ890847 - Synthetic construct Homo sapiens clone ccsbBroadEn_00241 CCT6A gene, encodes complete protein. AB209728 - Homo sapiens mRNA for chaperonin containing TCP1, subunit 6A isoform a variant protein. AM295155 - Homo sapiens partial mRNA for chaperonin subunit 6A (CCT6A gene). DQ599192 - Homo sapiens piRNA piR-37258, complete sequence. DQ599636 - Homo sapiens piRNA piR-37702, complete sequence. M94083 - Human chaperonin-like protein (HTR3) mRNA, complete cds. DQ578910 - Homo sapiens piRNA piR-47022, complete sequence. LF206968 - JP 2014500723-A/14471: Polycomb-Associated Non-Coding RNAs. LF359771 - JP 2014500723-A/167274: Polycomb-Associated Non-Coding RNAs. LF359772 - JP 2014500723-A/167275: Polycomb-Associated Non-Coding RNAs. JD501317 - Sequence 482341 from Patent EP1572962. LF359773 - JP 2014500723-A/167276: Polycomb-Associated Non-Coding RNAs. JD038887 - Sequence 19911 from Patent EP1572962. JD038888 - Sequence 19912 from Patent EP1572962. LF359774 - JP 2014500723-A/167277: Polycomb-Associated Non-Coding RNAs. JD023436 - Sequence 4460 from Patent EP1572962. JD032768 - Sequence 13792 from Patent EP1572962. LF359775 - JP 2014500723-A/167278: Polycomb-Associated Non-Coding RNAs. JD024241 - Sequence 5265 from Patent EP1572962. JD034674 - Sequence 15698 from Patent EP1572962. LF359776 - JP 2014500723-A/167279: Polycomb-Associated Non-Coding RNAs. JD185270 - Sequence 166294 from Patent EP1572962. JD066217 - Sequence 47241 from Patent EP1572962. JD375289 - Sequence 356313 from Patent EP1572962. JD090041 - Sequence 71065 from Patent EP1572962. MA442545 - JP 2018138019-A/14471: Polycomb-Associated Non-Coding RNAs. MA595348 - JP 2018138019-A/167274: Polycomb-Associated Non-Coding RNAs. MA595349 - JP 2018138019-A/167275: Polycomb-Associated Non-Coding RNAs. MA595350 - JP 2018138019-A/167276: Polycomb-Associated Non-Coding RNAs. MA595351 - JP 2018138019-A/167277: Polycomb-Associated Non-Coding RNAs. MA595352 - JP 2018138019-A/167278: Polycomb-Associated Non-Coding RNAs. MA595353 - JP 2018138019-A/167279: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P40227 (Reactome details) participates in the following event(s):
R-HSA-389954 Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC R-HSA-389961 ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex R-HSA-389970 Actin/tubulin:prefoldin complex associates with CCT/TriC R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone) R-HSA-391266 Association of CCT/TriC with sphingosine kinase 1 R-HSA-6814119 TRiC/CCT binds unfolded G-protein beta subunit R-HSA-390453 Hydrolysis of ATP and release of folded actin from CCT/TriC R-HSA-8850527 PDCL releases folded G-beta from TRiC/CCT R-HSA-8850539 Release of GNB5:RGS dimers from CCT/TRiC R-HSA-390459 Exchange of ADP for ATP in CCT/TriC:actin complex R-HSA-6814124 ATP binds G-protein beta associated TRiC/CCT R-HSA-8850529 RGS proteins bind GNB5 and CCT/TRiC R-HSA-8850534 PDCL promotes G-protein beta 5 folding R-HSA-6814121 PDCL binds G-protein beta and TRiC/CCT R-HSA-6814120 ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-390450 Folding of actin by CCT/TriC R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
