ID:CCNK_HUMAN DESCRIPTION: RecName: Full=Cyclin-K; FUNCTION: May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK). SUBUNIT: Part of a cyclin-kinase pair in the RNA polymerase II holoenzyme. Binds to CDK9. INTERACTION: P54253:ATXN1; NbExp=2; IntAct=EBI-739806, EBI-930964; TISSUE SPECIFICITY: Ubiquitously expressed. Highest levels in testis. SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily. WEB RESOURCE: Name=NIEHS SNPs; URL="http://egp.gs.washington.edu/data/ccnk/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75909
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004674 protein serine/threonine kinase activity GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0005515 protein binding GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0019901 protein kinase binding
Biological Process: GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006468 protein phosphorylation GO:0006974 cellular response to DNA damage stimulus GO:0007049 cell cycle GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0044828 negative regulation by host of viral genome replication GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051301 cell division GO:0071157 negative regulation of cell cycle arrest GO:2001165 positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
DQ893538 - Synthetic construct clone IMAGE:100006168; FLH164538.01X; RZPDo839H04162D cyclin K (CCNK) gene, encodes complete protein. EU176485 - Synthetic construct Homo sapiens clone IMAGE:100011337; FLH164537.01L; RZPDo839F02253D cyclin K (CCNK) gene, encodes complete protein. BC015935 - Homo sapiens cyclin K, mRNA (cDNA clone MGC:9113 IMAGE:3907416), complete cds. AK311075 - Homo sapiens cDNA, FLJ18117. AF060515 - Homo sapiens cyclin K (CPR4) mRNA, complete cds. CU677519 - Synthetic construct Homo sapiens gateway clone IMAGE:100017077 5' read CCNK mRNA. BT006950 - Homo sapiens cyclin K mRNA, complete cds. KJ904610 - Synthetic construct Homo sapiens clone ccsbBroadEn_14004 CCNK gene, encodes complete protein. AB209373 - Homo sapiens premature mRNA for CS0DA006YC23 variant. BX247958 - human full-length cDNA clone CS0DA006YC23 of Neuroblastoma of Homo sapiens (human). AK000799 - Homo sapiens cDNA FLJ20792 fis, clone COL01292. JD304789 - Sequence 285813 from Patent EP1572962. JD214834 - Sequence 195858 from Patent EP1572962. JD113597 - Sequence 94621 from Patent EP1572962. JD415690 - Sequence 396714 from Patent EP1572962. JD062739 - Sequence 43763 from Patent EP1572962. JD244291 - Sequence 225315 from Patent EP1572962. JD357890 - Sequence 338914 from Patent EP1572962. JD087193 - Sequence 68217 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O75909 (Reactome details) participates in the following event(s):
R-HSA-6797090 CCNK binds CDK12 R-HSA-6797100 CCNK binds CDK13 R-HSA-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes R-HSA-112430 Formation of P-TEFb complex R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes R-HSA-112381 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex R-HSA-167084 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex R-HSA-6810234 General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene R-HSA-113429 Elongating transcript encounters a lesion in the template R-HSA-112379 Recruitment of elongation factors to form elongation complex R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest R-HSA-112385 Addition of nucleotides leads to transcript elongation R-HSA-112392 Resumption of elongation after recovery from pausing R-HSA-113413 TFIIS-mediated recovery of elongation from arrest R-HSA-112395 Abortive termination of elongation after arrest R-HSA-112396 Separation of elongating transcript from template R-HSA-167077 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-167282 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167284 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167288 TFIIS-mediated recovery of HIV-1 elongation from arrest R-HSA-167292 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167481 Abortive termination of HIV-1 elongation after arrest R-HSA-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain R-HSA-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA R-HSA-2176475 Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-73857 RNA Polymerase II Transcription R-HSA-212436 Generic Transcription Pathway R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-167287 HIV elongation arrest and recovery R-HSA-167172 Transcription of the HIV genome R-HSA-74160 Gene expression (Transcription) R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-162587 HIV Life Cycle R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-162906 HIV Infection R-HSA-9006936 Signaling by TGF-beta family members R-HSA-5663205 Infectious disease R-HSA-162582 Signal Transduction R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
