Human Gene CCL19 (ENST00000311925.7_11) from GENCODE V47lift37
  Description: C-C motif chemokine ligand 19 (from RefSeq NM_006274.3)
Gencode Transcript: ENST00000311925.7_11
Gencode Gene: ENSG00000172724.12_12
Transcript (Including UTRs)
   Position: hg19 chr9:34,689,567-34,691,273 Size: 1,707 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr9:34,689,816-34,691,136 Size: 1,321 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:34,689,567-34,691,273)mRNA (may differ from genome)Protein (98 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCL19_HUMAN
DESCRIPTION: RecName: Full=C-C motif chemokine 19; AltName: Full=Beta-chemokine exodus-3; AltName: Full=CK beta-11; AltName: Full=Epstein-Barr virus-induced molecule 1 ligand chemokine; Short=EBI1 ligand chemokine; Short=ELC; AltName: Full=Macrophage inflammatory protein 3 beta; Short=MIP-3-beta; AltName: Full=Small-inducible cytokine A19; Flags: Precursor;
FUNCTION: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.
SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
WEB RESOURCE: Name=Wikipedia; Note=CCL19 entry; URL="http://en.wikipedia.org/wiki/CCL19";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCL19
Diseases sorted by gene-association score: chronic lymphocytic leukemia (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.94 RPKM in Artery - Coronary
Total median expression: 181.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.40137-0.142 Picture PostScript Text
3' UTR -77.90249-0.313 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000827 - Chemokine_CC_CS
IPR001811 - Chemokine_IL8-like_dom

Pfam Domains:
PF00048 - Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP Domains:
54117 - Interleukin 8-like chemokines

ModBase Predicted Comparative 3D Structure on Q99731
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0031732 CCR7 chemokine receptor binding
GO:0031735 CCR10 chemokine receptor binding
GO:0042379 chemokine receptor binding
GO:0048020 CCR chemokine receptor binding

Biological Process:
GO:0001768 establishment of T cell polarity
GO:0001771 immunological synapse formation
GO:0002407 dendritic cell chemotaxis
GO:0002408 myeloid dendritic cell chemotaxis
GO:0002548 monocyte chemotaxis
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007154 cell communication
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007257 activation of JUN kinase activity
GO:0009615 response to virus
GO:0010469 regulation of receptor activity
GO:0010560 positive regulation of glycoprotein biosynthetic process
GO:0019221 cytokine-mediated signaling pathway
GO:0031295 T cell costimulation
GO:0031640 killing of cells of other organism
GO:0032735 positive regulation of interleukin-12 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034695 response to prostaglandin E
GO:0042102 positive regulation of T cell proliferation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043547 positive regulation of GTPase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0045807 positive regulation of endocytosis
GO:0045860 positive regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0048247 lymphocyte chemotaxis
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048469 cell maturation
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050921 positive regulation of chemotaxis
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051897 positive regulation of protein kinase B signaling
GO:0060491 regulation of cell projection assembly
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071731 response to nitric oxide
GO:0072610 interleukin-12 secretion
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0097029 mature conventional dendritic cell differentiation
GO:0098586 cellular response to virus
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:2000147 positive regulation of cell motility
GO:2000549 positive regulation of dendritic cell dendrite assembly
GO:2000669 negative regulation of dendritic cell apoptotic process

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005623 cell


-  Descriptions from all associated GenBank mRNAs
  AB000887 - Homo sapiens ELC mRNA for EBI1-ligand chemokine, complete cds.
BC027968 - Homo sapiens chemokine (C-C motif) ligand 19, mRNA (cDNA clone MGC:34433 IMAGE:5225849), complete cds.
U77180 - Human macrophage inflammatory protein 3 beta (MIP-3beta) mRNA, complete cds.
AX772806 - Sequence 3 from Patent WO03046180.
JD492445 - Sequence 473469 from Patent EP1572962.
JD439222 - Sequence 420246 from Patent EP1572962.
JD437304 - Sequence 418328 from Patent EP1572962.
U88321 - Human beta chemokine Exodus-3 mRNA, complete cds.
CR456868 - Homo sapiens full open reading frame cDNA clone RZPDo834G0715D for gene CCL19, chemokine (C-C motif) ligand 19; complete cds, incl. stopcodon.
AK311945 - Homo sapiens cDNA, FLJ92213, Homo sapiens chemokine (C-C motif) ligand 19 (CCL19), mRNA.
KJ892110 - Synthetic construct Homo sapiens clone ccsbBroadEn_01504 CCL19 gene, encodes complete protein.
EU176240 - Synthetic construct Homo sapiens clone IMAGE:100006426; FLH182641.01X; RZPDo839G07250D chemokine (C-C motif) ligand 19 (CCL19) gene, encodes complete protein.
DQ895236 - Synthetic construct Homo sapiens clone IMAGE:100009696; FLH182634.01L; RZPDo839A06139D chemokine (C-C motif) ligand 19 (CCL19) gene, encodes complete protein.
AB590424 - Synthetic construct DNA, clone: pFN21AE1561, Homo sapiens CCL19 gene for chemokine (C-C motif) ligand 19, without stop codon, in Flexi system.
JD399761 - Sequence 380785 from Patent EP1572962.
JD409873 - Sequence 390897 from Patent EP1572962.
JD461969 - Sequence 442993 from Patent EP1572962.
JD386897 - Sequence 367921 from Patent EP1572962.
JD448060 - Sequence 429084 from Patent EP1572962.
JD227670 - Sequence 208694 from Patent EP1572962.
JD375304 - Sequence 356328 from Patent EP1572962.
JD392662 - Sequence 373686 from Patent EP1572962.
JD292899 - Sequence 273923 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q99731 (Reactome details) participates in the following event(s):

R-HSA-3296301 CCRL2 binds CCL19
R-HSA-373071 Receptor CCR7 binds CCL19 and 21 ligands
R-HSA-443978 Receptor CCR11 binds CCL19, CCL21 & CCL25
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-6783783 Interleukin-10 signaling
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-449147 Signaling by Interleukins
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: CCL19_HUMAN, ELC, ENST00000311925.1, ENST00000311925.2, ENST00000311925.3, ENST00000311925.4, ENST00000311925.5, ENST00000311925.6, MIP3B, NM_006274, O00697, O00736, Q99731, SCYA19, uc317pcq.1, uc317pcq.2
UCSC ID: ENST00000311925.7_11
RefSeq Accession: NM_006274.3
Protein: Q99731 (aka CCL19_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.