ID:CCL18_HUMAN DESCRIPTION: RecName: Full=C-C motif chemokine 18; AltName: Full=Alternative macrophage activation-associated CC chemokine 1; Short=AMAC-1; AltName: Full=CC chemokine PARC; AltName: Full=Dendritic cell chemokine 1; Short=DC-CK1; AltName: Full=Macrophage inflammatory protein 4; Short=MIP-4; AltName: Full=Pulmonary and activation-regulated chemokine; AltName: Full=Small-inducible cytokine A18; Contains: RecName: Full=CCL18(1-68); Contains: RecName: Full=CCL18(3-69); Contains: RecName: Full=CCL18(4-69); Flags: Precursor; FUNCTION: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. INTERACTION: Q9BZ71:PITPNM3; NbExp=4; IntAct=EBI-711240, EBI-2815766; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. INDUCTION: Specifically induced in macrophages by IL4/interleukin- 4, IL13/interleukin-13, and IL10/interleukin-10. Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937 cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB. MASS SPECTROMETRY: Mass=7849.4; Method=Electrospray; Range=21-89; Source=PubMed:11745396; MASS SPECTROMETRY: Mass=7652.1; Method=Electrospray; Range=23-89; Source=PubMed:11745396; MASS SPECTROMETRY: Mass=7552.0; Method=Electrospray; Range=24-89; Source=PubMed:11745396; SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. WEB RESOURCE: Name=Wikipedia; Note=CCL18 entry; URL="http://en.wikipedia.org/wiki/CCL18";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55774
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
