ID:Q2TNI1_HUMAN DESCRIPTION: RecName: Full=Caveolin; FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein (By similarity). SIMILARITY: Belongs to the caveolin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q2TNI1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0016504 peptidase activator activity GO:0019901 protein kinase binding GO:0030674 protein binding, bridging GO:0032947 protein complex scaffold GO:0046982 protein heterodimerization activity GO:0050998 nitric-oxide synthase binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000188 inactivation of MAPK activity GO:0001525 angiogenesis GO:0001570 vasculogenesis GO:0001666 response to hypoxia GO:0001937 negative regulation of endothelial cell proliferation GO:0001960 negative regulation of cytokine-mediated signaling pathway GO:0002026 regulation of the force of heart contraction GO:0002931 response to ischemia GO:0003057 regulation of the force of heart contraction by chemical signal GO:0006641 triglyceride metabolic process GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006940 regulation of smooth muscle contraction GO:0007519 skeletal muscle tissue development GO:0007595 lactation GO:0008104 protein localization GO:0008285 negative regulation of cell proliferation GO:0009968 negative regulation of signal transduction GO:0010524 positive regulation of calcium ion transport into cytosol GO:0010608 posttranscriptional regulation of gene expression GO:0010628 positive regulation of gene expression GO:0010952 positive regulation of peptidase activity GO:0019217 regulation of fatty acid metabolic process GO:0019915 lipid storage GO:0030857 negative regulation of epithelial cell differentiation GO:0030879 mammary gland development GO:0031397 negative regulation of protein ubiquitination GO:0033484 nitric oxide homeostasis GO:0042310 vasoconstriction GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein GO:0042632 cholesterol homeostasis GO:0043085 positive regulation of catalytic activity GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0043627 response to estrogen GO:0045019 negative regulation of nitric oxide biosynthetic process GO:0045907 positive regulation of vasoconstriction GO:0046426 negative regulation of JAK-STAT cascade GO:0051001 negative regulation of nitric-oxide synthase activity GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051592 response to calcium ion GO:0051899 membrane depolarization GO:0052547 regulation of peptidase activity GO:0055074 calcium ion homeostasis GO:0060056 mammary gland involution GO:0060546 negative regulation of necroptotic process GO:0061099 negative regulation of protein tyrosine kinase activity GO:0070836 caveola assembly GO:0071375 cellular response to peptide hormone stimulus GO:0071560 cellular response to transforming growth factor beta stimulus GO:0086091 regulation of heart rate by cardiac conduction GO:0086098 angiotensin-activated signaling pathway involved in heart process GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0098911 regulation of ventricular cardiac muscle cell action potential GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1903598 positive regulation of gap junction assembly GO:2000811 negative regulation of anoikis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
