ID:CAR10_HUMAN DESCRIPTION: RecName: Full=Caspase recruitment domain-containing protein 10; AltName: Full=CARD-containing MAGUK protein 3; Short=Carma 3; FUNCTION: Activates NF-kappa-B via BCL10 and IKK. SUBUNIT: CARD10 and BCL10 bind to each other by CARD-CARD interaction. They both participate in a complex with MALT1, where MALT1 binds to BCL10 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney. SIMILARITY: Contains 1 CARD domain. CAUTION: Supposed to contain a SH3, a PDZ and a guanylate kinase- like domain. But none of these 3 domains are detected by PROSITE, Pfam or SMART.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BWT7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007250 activation of NF-kappaB-inducing kinase activity GO:0042981 regulation of apoptotic process GO:0065003 macromolecular complex assembly GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis GO:1900182 positive regulation of protein localization to nucleus
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
